{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sahin SI"],"funding":["NIH HHS"],"pagination":["736-749"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10143874"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(2)"],"pubmed_abstract":["Metabolite-specific echo-planar imaging (EPI) sequences with spectral-spatial (spsp) excitation are commonly used in clinical hyperpolarized [1-<sup>13</sup>C]pyruvate studies because of their speed, efficiency, and flexibility. In contrast, preclinical systems typically rely on slower spectroscopic methods, such as chemical shift imaging (CSI). In this study, a 2D spspEPI sequence was developed for use on a preclinical 3T Bruker system and tested on in vivo mice experiments with patient-derived xenograft renal cell carcinoma (RCC) or prostate cancer tissues implanted in the kidney or liver. Compared to spspEPI sequences, CSI were found to have a broader point spread function via simulations and exhibited signal bleeding between vasculature and tumors in vivo. Parameters for the spspEPI se"],"journal":["Tomography (Ann Arbor, Mich.)"],"pubmed_title":["Metabolite-Specific Echo Planar Imaging for Preclinical Studies with Hyperpolarized <sup>13</sup>C-Pyruvate MRI."],"pmcid":["PMC10143874"],"funding_grant_id":["R01CA249909","P41EB013598","U24CA253377"],"pubmed_authors":["Mattingly M","Sinha A","Gordon JW","Ji X","Mali I","Agarwal S","Sahin SI","Kurhanewicz J","Subramaniam S","Larson PEZ","Sriram R"],"additional_accession":[]},"is_claimable":false,"name":"Metabolite-Specific Echo Planar Imaging for Preclinical Studies with Hyperpolarized <sup>13</sup>C-Pyruvate MRI.","description":"Metabolite-specific echo-planar imaging (EPI) sequences with spectral-spatial (spsp) excitation are commonly used in clinical hyperpolarized [1-<sup>13</sup>C]pyruvate studies because of their speed, efficiency, and flexibility. In contrast, preclinical systems typically rely on slower spectroscopic methods, such as chemical shift imaging (CSI). In this study, a 2D spspEPI sequence was developed for use on a preclinical 3T Bruker system and tested on in vivo mice experiments with patient-derived xenograft renal cell carcinoma (RCC) or prostate cancer tissues implanted in the kidney or liver. Compared to spspEPI sequences, CSI were found to have a broader point spread function via simulations and exhibited signal bleeding between vasculature and tumors in vivo. Parameters for the spspEPI se","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-18T16:29:57.604Z","creation":"2025-04-07T03:43:29.302Z"},"accession":"S-EPMC10143874","cross_references":{"pubmed":["37104130"],"doi":["10.3390/tomography9020059"]}}