biostudies-literatureEstrella-Maldonado HConsejo Veracruzano de Investigación Científica y Desarrollo Tecnológico7497https://www.ebi.ac.uk/biostudies/studies/S-EPMC10144405biostudies-literatureUnknown24(8)Huanglongbing (HLB) is a vascular disease of <i>Citrus</i> caused by three species of the α-proteobacteria "<i>Candidatus</i> Liberibacter", with "<i>Candidatus</i> Liberibacter asiaticus" (<i>C</i>Las) being the most widespread and the one causing significant economic losses in citrus-producing regions worldwide. However, Persian lime (<i>Citrus latifolia</i> Tanaka) has shown tolerance to the disease. To understand the molecular mechanisms of this tolerance, transcriptomic analysis of HLB was performed using asymptomatic and symptomatic leaves. RNA-Seq analysis revealed 652 differentially expressed genes (DEGs) in response to <i>C</i>Las infection, of which 457 were upregulated and 195 were downregulated. KEGG analysis revealed that after <i>C</i>Las infection, some DEGs were present in International journal of molecular sciencesInsights into the Molecular Basis of Huanglongbing Tolerance in Persian Lime (<i>Citrus latifolia</i> Tan.) through a Transcriptomic Approach.PMC1014440515 1906/2021Estrella-Maldonado HSantamaria JMGonzalez-Cruz CMatilde-Hernandez CAdame-Garcia JFlores-de la Rosa FRSantillan-Mendoza RfalseInsights into the Molecular Basis of Huanglongbing Tolerance in Persian Lime (<i>Citrus latifolia</i> Tan.) through a Transcriptomic Approach.Huanglongbing (HLB) is a vascular disease of <i>Citrus</i> caused by three species of the α-proteobacteria "<i>Candidatus</i> Liberibacter", with "<i>Candidatus</i> Liberibacter asiaticus" (<i>C</i>Las) being the most widespread and the one causing significant economic losses in citrus-producing regions worldwide. However, Persian lime (<i>Citrus latifolia</i> Tanaka) has shown tolerance to the disease. To understand the molecular mechanisms of this tolerance, transcriptomic analysis of HLB was performed using asymptomatic and symptomatic leaves. RNA-Seq analysis revealed 652 differentially expressed genes (DEGs) in response to <i>C</i>Las infection, of which 457 were upregulated and 195 were downregulated. KEGG analysis revealed that after <i>C</i>Las infection, some DEGs were present in 2023-01-01T00:00:00Z2023 Apr2025-04-04T19:18:51.47Z2025-04-04T19:18:51.47ZS-EPMC101444053710866210.3390/ijms24087497