biostudies-literatureSnyder BMNIH HHS510https://www.ebi.ac.uk/biostudies/studies/S-EPMC10144800biostudies-literatureUnknown13(4)We aimed first to assess associations between maternal health characteristics and newborn metabolite concentrations and second to assess associations between metabolites associated with maternal health characteristics and child body mass index (BMI). This study included 3492 infants enrolled in three birth cohorts with linked newborn screening metabolic data. Maternal health characteristics were ascertained from questionnaires, birth certificates, and medical records. Child BMI was ascertained from medical records and study visits. We used multivariate analysis of variance, followed by multivariable linear/proportional odds regression, to determine maternal health characteristic-newborn metabolite associations. Significant associations were found in discovery and replication cohorts of higMetabolitesThe Associations of Maternal Health Characteristics, Newborn Metabolite Concentrations, and Child Body Mass Index among US Children in the ECHO Program.PMC10144800UH3 OD023285U19 AI095227U24OD023319UH3 OD023288K01 HL161257UG3/UH3 OD023282UH3 OD023248U24OD023382U2COD023375Ryckman KKWu PMcEvoy CTPaneth NSDupont WDOn Behalf Of Program Collaborators For Environmental Influences On Child Health OutcomesGern JESnyder BMGebretsadik TFry RCHartert TVRohrig NBDabelea DMLynch SVfalseThe Associations of Maternal Health Characteristics, Newborn Metabolite Concentrations, and Child Body Mass Index among US Children in the ECHO Program.We aimed first to assess associations between maternal health characteristics and newborn metabolite concentrations and second to assess associations between metabolites associated with maternal health characteristics and child body mass index (BMI). This study included 3492 infants enrolled in three birth cohorts with linked newborn screening metabolic data. Maternal health characteristics were ascertained from questionnaires, birth certificates, and medical records. Child BMI was ascertained from medical records and study visits. We used multivariate analysis of variance, followed by multivariable linear/proportional odds regression, to determine maternal health characteristic-newborn metabolite associations. Significant associations were found in discovery and replication cohorts of hig2023-01-01T00:00:00Z2023 Apr2025-04-22T08:47:20.48Z2025-04-05T22:44:53.165ZS-EPMC101448003711016810.3390/metabo13040510