biostudies-literatureUnknown15(4)Nguyen NNSince the discovery of SARS-CoV-2, changes in genotype and reinfection with different variants have been observed in COVID-19-recovered patients, raising questions around the clinical pattern and severity of primary infection and reinfection. In this systematic review, we summarize the results of 23 studies addressing SARS-CoV-2 reinfections. A total of 23,231 reinfected patients were included, with pooled estimated reinfection rates ranging from 0.1 to 6.8%. Reinfections were more prevalent during the Omicron variant period. The mean age of reinfected patients was 38.0 ± 6. years and females were predominant among reinfected patients (M/F = 0.8). The most common symptoms during the first and second infection were fever (41.1%), cough (35.7% and 44.6%), myalgia (34.5% and 33.3%), fatigue (Viruses967https://www.ebi.ac.uk/biostudies/studies/S-EPMC10145185biostudies-literatureSARS-CoV-2 Reinfection and Severity of the Disease: A Systematic Review and Meta-Analysis.PMC10145185Hoang VTMillion MNguyen NNGautret PNguyen YNfalseSARS-CoV-2 Reinfection and Severity of the Disease: A Systematic Review and Meta-Analysis.Since the discovery of SARS-CoV-2, changes in genotype and reinfection with different variants have been observed in COVID-19-recovered patients, raising questions around the clinical pattern and severity of primary infection and reinfection. In this systematic review, we summarize the results of 23 studies addressing SARS-CoV-2 reinfections. A total of 23,231 reinfected patients were included, with pooled estimated reinfection rates ranging from 0.1 to 6.8%. Reinfections were more prevalent during the Omicron variant period. The mean age of reinfected patients was 38.0 ± 6. years and females were predominant among reinfected patients (M/F = 0.8). The most common symptoms during the first and second infection were fever (41.1%), cough (35.7% and 44.6%), myalgia (34.5% and 33.3%), fatigue (2023-01-01T00:00:00Z2023 Apr2025-04-21T17:27:16.273Z2025-04-05T16:40:52.443ZS-EPMC101451853711294910.3390/v15040967