{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Seo YH"],"funding":["Korea Institute of Oriental Medicine"],"pagination":["1726"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10146194"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(8)"],"pubmed_abstract":["In total, four new eudesmane-type sesquiterpene glycosides, askoseosides A-D (<b>1</b>-<b>4</b>), and 18 known compounds (<b>5</b>-<b>22</b>) were isolated from the flowers of <i>Aster koraiensis</i> via chromatographic techniques. Chemical structures of the isolated compounds were identified by spectroscopic/spectrometric methods, including NMR and HRESIMS, and the absolute configuration of the new compounds (<b>1</b> and <b>2</b>) was performed by electronic circular dichroism (ECD) studies. Further, the anticancer activities of the isolated compounds (<b>1</b>-<b>22</b>) were evaluated using the epidermal growth factor (EGF)-induced as well as the 12-<i>O</i>-tetradecanoylphorbol 13-acetate (TPA)-induced cell transformation assay. Among the 22 compounds, compounds <b>4</b>, <b>9</b>, <b"],"journal":["Plants (Basel, Switzerland)"],"pubmed_title":["New Sesquiterpene Glycosides from the Flowers of <i>Aster koraiensis</i> and Their Inhibition Activities on EGF- and TPA-Induced Cell Transformation."],"pmcid":["PMC10146194"],"funding_grant_id":["KSN2012320"],"pubmed_authors":["Ryu SM","Lee MH","Lee AY","Kim JY","Seo YH","Hwang SY","Moon BC","Lee J","Kim HS","Kim N","Son H","Jang DS"],"additional_accession":[]},"is_claimable":false,"name":"New Sesquiterpene Glycosides from the Flowers of <i>Aster koraiensis</i> and Their Inhibition Activities on EGF- and TPA-Induced Cell Transformation.","description":"In total, four new eudesmane-type sesquiterpene glycosides, askoseosides A-D (<b>1</b>-<b>4</b>), and 18 known compounds (<b>5</b>-<b>22</b>) were isolated from the flowers of <i>Aster koraiensis</i> via chromatographic techniques. Chemical structures of the isolated compounds were identified by spectroscopic/spectrometric methods, including NMR and HRESIMS, and the absolute configuration of the new compounds (<b>1</b> and <b>2</b>) was performed by electronic circular dichroism (ECD) studies. Further, the anticancer activities of the isolated compounds (<b>1</b>-<b>22</b>) were evaluated using the epidermal growth factor (EGF)-induced as well as the 12-<i>O</i>-tetradecanoylphorbol 13-acetate (TPA)-induced cell transformation assay. Among the 22 compounds, compounds <b>4</b>, <b>9</b>, <b","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T19:18:07.607Z","creation":"2025-04-04T19:18:07.607Z"},"accession":"S-EPMC10146194","cross_references":{"pubmed":["37111949"],"doi":["10.3390/plants12081726"]}}