{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Owusu DO"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["855"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10146292"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["<i>Mycobacterium (M.) bovis</i> BCG vaccination is recommended for healthy babies after birth in several countries with a high prevalence of tuberculosis, including Ghana. Previous studies showed that BCG vaccination prevents individuals from developing severe clinical manifestations of tuberculosis, but BCG vaccination effects on the induction of IFN-γ after <i>M. tuberculosis</i> infection have hardly been investigated. Here, we performed IFN-γ-based T-cell assays (i.e., IFN-γ Release Assay, IGRA; T-cell activation and maturation marker assay, TAM-TB) in children who had contact with index tuberculosis patients (contacts). These contacts were classified as either being BCG vaccinated at birth (<i>n</i> = 77) or non-BCG-vaccinated (<i>n</i> = 17) and were followed up at three timepoints f"],"journal":["Vaccines"],"pubmed_title":["BCG-Vaccinated Children with Contact to Tuberculosis Patients Show Delayed Conversion of <i>Mycobacterium tuberculosis</i>-Specific IFN-γ Release."],"pmcid":["PMC10146292"],"funding_grant_id":["JA 1479/9-1"],"pubmed_authors":["Abass MK","Mayatepek E","Yeboah A","Acheampong I","Batsa Debrah L","Jacobsen M","Lamptey M","Kumbel F","Phillips RO","Osei-Yeboah F","Arthur JF","Debrah A","Owusu DO","Seyfarth J","Aniagyei W","Minadzi D","Adankwah E","Vivekanandan MM","Gawusu A"],"additional_accession":[]},"is_claimable":false,"name":"BCG-Vaccinated Children with Contact to Tuberculosis Patients Show Delayed Conversion of <i>Mycobacterium tuberculosis</i>-Specific IFN-γ Release.","description":"<i>Mycobacterium (M.) bovis</i> BCG vaccination is recommended for healthy babies after birth in several countries with a high prevalence of tuberculosis, including Ghana. Previous studies showed that BCG vaccination prevents individuals from developing severe clinical manifestations of tuberculosis, but BCG vaccination effects on the induction of IFN-γ after <i>M. tuberculosis</i> infection have hardly been investigated. Here, we performed IFN-γ-based T-cell assays (i.e., IFN-γ Release Assay, IGRA; T-cell activation and maturation marker assay, TAM-TB) in children who had contact with index tuberculosis patients (contacts). These contacts were classified as either being BCG vaccinated at birth (<i>n</i> = 77) or non-BCG-vaccinated (<i>n</i> = 17) and were followed up at three timepoints f","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-05T10:01:42.935Z","creation":"2025-04-05T10:01:42.935Z"},"accession":"S-EPMC10146292","cross_references":{"pubmed":["37112767"],"doi":["10.3390/vaccines11040855"]}}