biostudies-literatureOwusu DODeutsche Forschungsgemeinschaft855https://www.ebi.ac.uk/biostudies/studies/S-EPMC10146292biostudies-literatureUnknown11(4)<i>Mycobacterium (M.) bovis</i> BCG vaccination is recommended for healthy babies after birth in several countries with a high prevalence of tuberculosis, including Ghana. Previous studies showed that BCG vaccination prevents individuals from developing severe clinical manifestations of tuberculosis, but BCG vaccination effects on the induction of IFN-γ after <i>M. tuberculosis</i> infection have hardly been investigated. Here, we performed IFN-γ-based T-cell assays (i.e., IFN-γ Release Assay, IGRA; T-cell activation and maturation marker assay, TAM-TB) in children who had contact with index tuberculosis patients (contacts). These contacts were classified as either being BCG vaccinated at birth (<i>n</i> = 77) or non-BCG-vaccinated (<i>n</i> = 17) and were followed up at three timepoints fVaccinesBCG-Vaccinated Children with Contact to Tuberculosis Patients Show Delayed Conversion of <i>Mycobacterium tuberculosis</i>-Specific IFN-γ Release.PMC10146292JA 1479/9-1Abass MKMayatepek EYeboah AAcheampong IBatsa Debrah LJacobsen MLamptey MKumbel FPhillips ROOsei-Yeboah FArthur JFDebrah AOwusu DOSeyfarth JAniagyei WMinadzi DAdankwah EVivekanandan MMGawusu AfalseBCG-Vaccinated Children with Contact to Tuberculosis Patients Show Delayed Conversion of <i>Mycobacterium tuberculosis</i>-Specific IFN-γ Release.<i>Mycobacterium (M.) bovis</i> BCG vaccination is recommended for healthy babies after birth in several countries with a high prevalence of tuberculosis, including Ghana. Previous studies showed that BCG vaccination prevents individuals from developing severe clinical manifestations of tuberculosis, but BCG vaccination effects on the induction of IFN-γ after <i>M. tuberculosis</i> infection have hardly been investigated. Here, we performed IFN-γ-based T-cell assays (i.e., IFN-γ Release Assay, IGRA; T-cell activation and maturation marker assay, TAM-TB) in children who had contact with index tuberculosis patients (contacts). These contacts were classified as either being BCG vaccinated at birth (<i>n</i> = 77) or non-BCG-vaccinated (<i>n</i> = 17) and were followed up at three timepoints f2023-01-01T00:00:00Z2023 Apr2025-04-05T10:01:42.935Z2025-04-05T10:01:42.935ZS-EPMC101462923711276710.3390/vaccines11040855