{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lim H"],"funding":["Korean Health Industry Development Institute","National Research Foundation of Korea"],"pagination":["712"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10146744"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(4)"],"pubmed_abstract":["An early and accurate diagnosis of Candida albicans is critical for the rapid antifungal treatment of candidemia, a mortal bloodstream infection. This study demonstrates viscoelastic microfluidic techniques for continuous separation, concentration, and subsequent washing of Candida cells in the blood. The total sample preparation system contains two-step microfluidic devices: a closed-loop separation and concentration device and a co-flow cell-washing device. To determine the flow conditions of the closed-loop device, such as the flow rate factor, a mixture of 4 and 13 μm particles was used. Candida cells were successfully separated from the white blood cells (WBCs) and concentrated by 74.6-fold in the sample reservoir of the closed-loop system at 800 μL/min with a flow rate factor of 3.3."],"journal":["Micromachines"],"pubmed_title":["Separation and Washing of Candida Cells from White Blood Cells Using Viscoelastic Microfluidics."],"pmcid":["PMC10146744"],"funding_grant_id":["HR20C0021","2020R1A2C1014460"],"pubmed_authors":["Lee C","Kim JY","Han BJ","Lim H","Choo S","Lim CS","Nam J"],"additional_accession":[]},"is_claimable":false,"name":"Separation and Washing of Candida Cells from White Blood Cells Using Viscoelastic Microfluidics.","description":"An early and accurate diagnosis of Candida albicans is critical for the rapid antifungal treatment of candidemia, a mortal bloodstream infection. This study demonstrates viscoelastic microfluidic techniques for continuous separation, concentration, and subsequent washing of Candida cells in the blood. The total sample preparation system contains two-step microfluidic devices: a closed-loop separation and concentration device and a co-flow cell-washing device. To determine the flow conditions of the closed-loop device, such as the flow rate factor, a mixture of 4 and 13 μm particles was used. Candida cells were successfully separated from the white blood cells (WBCs) and concentrated by 74.6-fold in the sample reservoir of the closed-loop system at 800 μL/min with a flow rate factor of 3.3.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-07-09T03:04:24.041Z","creation":"2025-04-07T03:52:40.494Z"},"accession":"S-EPMC10146744","cross_references":{"pubmed":["37420947"],"doi":["10.3390/mi14040712"]}}