{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(17)"],"submitter":["Yang N"],"pubmed_abstract":["Remote C-H functionalization is highly important for the conversion and utilization of arenes, but the conventional routes are comprehensively developed with the assistance of transition metal catalysts or templates. We report a facile metal/template-free electrochemical strategy for remote C-H functionalization in a helical system, where aromatic or aliphatic hydrogen act as a directing group to promote the alkoxylation at the opposite site of the helical skeleton by generating a unique helical \"back-biting\" environment. Such helicity-modulated C-H functionalization is prevalent for carbo[<i>n</i>]helicenes (<i>n</i> = 6 to 9, primitive or substituted) and hetero[6]helicenes and also occurs when the aryl hydrogen on the first position is replaced by a methyl group or a phenyl group. Thus,"],"journal":["Science advances"],"pagination":["eadg6680"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10146887"],"repository":["biostudies-literature"],"pubmed_title":["Helicity-modulated remote C-H functionalization."],"pmcid":["PMC10146887"],"pubmed_authors":["Zhang G","Ding Y","Qiu H","Crassous J","Yang N","Shen C","Gan F"],"additional_accession":[]},"is_claimable":false,"name":"Helicity-modulated remote C-H functionalization.","description":"Remote C-H functionalization is highly important for the conversion and utilization of arenes, but the conventional routes are comprehensively developed with the assistance of transition metal catalysts or templates. We report a facile metal/template-free electrochemical strategy for remote C-H functionalization in a helical system, where aromatic or aliphatic hydrogen act as a directing group to promote the alkoxylation at the opposite site of the helical skeleton by generating a unique helical \"back-biting\" environment. Such helicity-modulated C-H functionalization is prevalent for carbo[<i>n</i>]helicenes (<i>n</i> = 6 to 9, primitive or substituted) and hetero[6]helicenes and also occurs when the aryl hydrogen on the first position is replaced by a methyl group or a phenyl group. Thus,","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-19T05:26:13.647Z","creation":"2025-04-19T05:26:13.647Z"},"accession":"S-EPMC10146887","cross_references":{"pubmed":["37115920"],"doi":["10.1126/sciadv.adg6680"]}}