biostudies-literatureUnknown9(17)Yang NRemote C-H functionalization is highly important for the conversion and utilization of arenes, but the conventional routes are comprehensively developed with the assistance of transition metal catalysts or templates. We report a facile metal/template-free electrochemical strategy for remote C-H functionalization in a helical system, where aromatic or aliphatic hydrogen act as a directing group to promote the alkoxylation at the opposite site of the helical skeleton by generating a unique helical "back-biting" environment. Such helicity-modulated C-H functionalization is prevalent for carbo[<i>n</i>]helicenes (<i>n</i> = 6 to 9, primitive or substituted) and hetero[6]helicenes and also occurs when the aryl hydrogen on the first position is replaced by a methyl group or a phenyl group. Thus,Science advanceseadg6680https://www.ebi.ac.uk/biostudies/studies/S-EPMC10146887biostudies-literatureHelicity-modulated remote C-H functionalization.PMC10146887Zhang GDing YQiu HCrassous JYang NShen CGan FfalseHelicity-modulated remote C-H functionalization.Remote C-H functionalization is highly important for the conversion and utilization of arenes, but the conventional routes are comprehensively developed with the assistance of transition metal catalysts or templates. We report a facile metal/template-free electrochemical strategy for remote C-H functionalization in a helical system, where aromatic or aliphatic hydrogen act as a directing group to promote the alkoxylation at the opposite site of the helical skeleton by generating a unique helical "back-biting" environment. Such helicity-modulated C-H functionalization is prevalent for carbo[<i>n</i>]helicenes (<i>n</i> = 6 to 9, primitive or substituted) and hetero[6]helicenes and also occurs when the aryl hydrogen on the first position is replaced by a methyl group or a phenyl group. Thus,2023-01-01T00:00:00Z2023 Apr2025-04-19T05:26:13.647Z2025-04-19T05:26:13.647ZS-EPMC101468873711592010.1126/sciadv.adg6680