{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Adolf LA"],"funding":["Fortuene Program University Hospital Tuebingen","Deutsche Forschungsgemeinschaft","Spanish Ministry of Science","German Center of Infection Research"],"pagination":["e85304"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10147376"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Sufficient access to transition metals such as iron is essential for bacterial proliferation and their active limitation within host tissues effectively restricts infection. To overcome iron limitation, the invasive pathogen <i>Staphylococcus aureus</i> uses the iron-regulated surface determinant (Isd) system to acquire hemoglobin-derived heme. While heme transport over the cell wall is well understood, its transport over the membrane is hardly investigated. In this study, we show the heme-specific permease IsdF to be energized by the general ATPase FhuC. Additionally, we show that IsdF needs appropriate location within the membrane for functionality. The membrane of <i>S. aureus</i> possesses special compartments (functional membrane microdomains [FMMs]) to organize membrane complexes. We"],"journal":["eLife"],"pubmed_title":["Functional membrane microdomains and the hydroxamate siderophore transporter ATPase FhuC govern Isd-dependent heme acquisition in <i>Staphylococcus aureus</i>."],"pmcid":["PMC10147376"],"funding_grant_id":["398967434 -TRR261","2507-0-0","EXC 2124 - 390838134","PID2020-115699GB-100","TTU 08.708_00"],"pubmed_authors":["Kricks L","Grein F","Muller-Jochim A","Heilbronner S","Adolf LA","Lopez D","Puls JS"],"additional_accession":[]},"is_claimable":false,"name":"Functional membrane microdomains and the hydroxamate siderophore transporter ATPase FhuC govern Isd-dependent heme acquisition in <i>Staphylococcus aureus</i>.","description":"Sufficient access to transition metals such as iron is essential for bacterial proliferation and their active limitation within host tissues effectively restricts infection. To overcome iron limitation, the invasive pathogen <i>Staphylococcus aureus</i> uses the iron-regulated surface determinant (Isd) system to acquire hemoglobin-derived heme. While heme transport over the cell wall is well understood, its transport over the membrane is hardly investigated. In this study, we show the heme-specific permease IsdF to be energized by the general ATPase FhuC. Additionally, we show that IsdF needs appropriate location within the membrane for functionality. The membrane of <i>S. aureus</i> possesses special compartments (functional membrane microdomains [FMMs]) to organize membrane complexes. We","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T19:18:31.13Z","creation":"2025-04-04T19:18:31.13Z"},"accession":"S-EPMC10147376","cross_references":{"pubmed":["37042640"],"doi":["10.7554/eLife.85304"]}}