{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou K"],"funding":["National Natural Science Foundation of China"],"pagination":["2464"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10147710"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Adaptation to selective pressures is crucial for clinically important pathogens to establish epidemics, but the underlying evolutionary drivers remain poorly understood. The current epidemic of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant threat to public health. In this study we analyzed the genome sequences of 794 CRKP bloodstream isolates collected in 40 hospitals in China between 2014 and 2019. We uncovered a subclonal replacement in the predominant clone ST11, where the previously prevalent subclone OL101:KL47 was replaced by O2v1:KL64 over time in a stepwise manner. O2v1:KL64 carried a higher load of mobile genetic elements, and a point mutation exclusively detected in the recC of O2v1:KL64 significantly promotes recombination proficiency. The epidemic succes"],"journal":["Nature communications"],"pubmed_title":["A point mutation in recC associated with subclonal replacement of carbapenem-resistant Klebsiella pneumoniae ST11 in China."],"pmcid":["PMC10147710"],"funding_grant_id":["81902030","82172330","81971984"],"pubmed_authors":["Hu S","Shen J","Dong Y","Quan B","Shen P","Man S","Zhang L","Luan L","Wang J","Wang L","Sun L","Wan C","Guo L","Gu B","Lam MMC","Dong H","Wang S","Liang J","Liang K","Chen Y","Kang J","Zhang B","Liao Z","Liao Y","Xia X","Xu R","Qiao D","Chen F","Xu H","Jin Y","Yang Z","Li Y","Li Z","Hu H","Du F","Xu T","Lin H","BRICS Working Group","Liu J","Ding H","Ma L","Cao J","Wyres KL","Mao H","Liu Q","Dai Y","Liu Y","Qi X","Wei S","Liao G","Zheng L","Li A","Zhou K","Xue CX","Xiao Y","Zhou Y","Yan X","Huang Y","Zhu L","Holt KE","Zhu W","Liu D"],"additional_accession":[]},"is_claimable":false,"name":"A point mutation in recC associated with subclonal replacement of carbapenem-resistant Klebsiella pneumoniae ST11 in China.","description":"Adaptation to selective pressures is crucial for clinically important pathogens to establish epidemics, but the underlying evolutionary drivers remain poorly understood. The current epidemic of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant threat to public health. In this study we analyzed the genome sequences of 794 CRKP bloodstream isolates collected in 40 hospitals in China between 2014 and 2019. We uncovered a subclonal replacement in the predominant clone ST11, where the previously prevalent subclone OL101:KL47 was replaced by O2v1:KL64 over time in a stepwise manner. O2v1:KL64 carried a higher load of mobile genetic elements, and a point mutation exclusively detected in the recC of O2v1:KL64 significantly promotes recombination proficiency. The epidemic succes","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-04-30T12:32:32.82Z","creation":"2024-11-12T07:05:48.483Z"},"accession":"S-EPMC10147710","cross_references":{"pubmed":["37117217"],"doi":["10.1038/s41467-023-38061-z"]}}