biostudies-literatureUnknown12(4)Ambrosioni J<h4>Introduction</h4>Infective endocarditis (IE) has undergone important changes in its epidemiology worldwide.<h4>Methods</h4>The study aimed to compare IE epidemiological features and outcomes according to predefined European regions and between two different time periods in the twenty-first century.<h4>Results</h4>IE cases from 13 European countries were included. Two periods were considered: 2000-2006 and 2008-2012. Two European regions were considered, according to the United Nations geoscheme for Europe: Southern (SE) and Northern-Central Europe (NCE). Comparisons were performed between regions and periods. A total of 4195 episodes of IE were included, 2113 from SE and 2082 from NCE; 2787 cases were included between 2000 and 2006 and 1408 between 2008 and 2012. Median (IQR) age was 6Infectious diseases and therapy1083-1101https://www.ebi.ac.uk/biostudies/studies/S-EPMC10147876biostudies-literatureEpidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000-2012).PMC10147876International Collaboration for Endocarditis (ICE) InvestigatorsGiannitsioti EChu VHSexton DAlauzet CAbidin ISexton DJBernard YKorem MLalani TCasabe JDe Feo MGoglio ADouglas PSuter FPachirat PPatel MRiddle JRizk HPachirat OCuervo GLeroy JCorey GRKotsanas DRamirez JPussadhamma BBaddley JOses PFAlla FFowler VGVinogradova TFernandez-Hidalgo NAthanasia SSalstrom SJKarchmer AWde Oliveira Ramos AButkevich OMFerraiuoli GGonzalez JDragulescu SAlmirante BDelahaye ADe Rosa FEykyn SPost JCuccurullo SMarin VGMBradley SMoreno AKanafani ZAmbrosioni JLattanzio MCorte ADVadim KPericas JMSiciliano RFJeu ABouza EPapanikolaou KGrossi PPapanicolaou KCasalta JPDiPersio JBonilla HRudez ILlopis JMella RMHansa CUrsi MPDrew LAndrade ARSkoutelis AOlaison LSignorini LSolis JRaglio ASitges MNeuerburg CJohansson MVieira MLCDeliolanis IImazio MToniolo AFortes CQChevalier FStryjewski MCovino FEAissa NKirill Ode Alarcon AAshour ZRubinstein EJones SBLiew YYAzqueta MTamin SSMichelet CZaloudikova BSharma GGuma JRPark LPFournier PEFrancis JDoco-Lecompte TStrahilevitz JKennedy KGarcia PVincelj JChipigina NWatkin RJones PThuny FKanj SSAnstrom KFuster DCarosi GCabell CHWiesbauer FStrabelli TMVCortes CRyan SHarkness JRizzi MMorris APaiva MGHannan MMRaoult DVidal BKauffman CCrowley ALRaymond NHernandez-Meneses MSelton-Suty CMornos CLogar MNinot SNacinovich FSharif-Yakan AGarcia-de-la-Maria CHarris OMorris AMQuintana Ede Brito ACPIonac ASnygg-Martin UFranco LMarco FFernandez MAGGolebiovski WRemadi JPTrinchero RMagri SDixon CCBedimo RRybak MJaramillo ANMansur AJVila JPangercic ALerakis SVenugopal KD'Amico FAlmela MFreiberger TFica AMurdoch DRCastro PDeetlefs ESanchez MPyros JFont BDonnio PYFlecher EForno DGuimaraes ACHoen BFernandez RHolland TCecchi ESandoval ERodriguez-Creixems MIsrael SLevine DRovira IChu VPaniara OMunoz PTornos PMiro JMBukovski SPeterson GHalim MMudrick DStafford JHabib GBermejo JKeynan YMartinez ERPare JCvan der Meer JTMDever RWray DTattevin PLamas CCereceda MCasey ABayer ASFeneley MPOrtiz JSenthong VAthan ETripodi MFAnguera ISucari AAltclas JMishaal MWeksler CBernardo MParra RMueller-Premru MThomas VPafundi PCDialetto GSteed LThomas TEdathodu JKonecny PFalces CRonderos RGarcia-Gonzalez JReinbott PDurante-Mangoni EPlesiat PDickerman SAHolland DDurack DTThierer JGrinberg MLejko-Zupanc TMazaheri BRoda JEyton CLambert PSamad ZWang ARevest MPedromingo MRees DCommerford PClara LPol JElliott TBaloch KSpelman DChirouze CAlestig ECampagnac CVandenesch FTan RSNtsekhe Mde Medeiros Tranchesi RAJones-Richmond MHurley JPEl Kholy ARusinaru DHurley JMoreillon PGattringer RKogan STolosana JMPapanicolas LRavasio VTan RNaber CTribouilloy CMylona EGilon DTellez ABarsic BIossa DManduca SGatell JMDelahaye FOsama DFita GNair LRead KCantey RStancoven AHarding TBrunet MNieto GISKorman TKrajinovic VDe Lazzari EKarlowsky JASanderford BLawrence RGiamarellou HKlein JLWanounou MChambers SWoods CWCommerford AGordon DOrlando SDonal EfalseEpidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000-2012).<h4>Introduction</h4>Infective endocarditis (IE) has undergone important changes in its epidemiology worldwide.<h4>Methods</h4>The study aimed to compare IE epidemiological features and outcomes according to predefined European regions and between two different time periods in the twenty-first century.<h4>Results</h4>IE cases from 13 European countries were included. Two periods were considered: 2000-2006 and 2008-2012. Two European regions were considered, according to the United Nations geoscheme for Europe: Southern (SE) and Northern-Central Europe (NCE). Comparisons were performed between regions and periods. A total of 4195 episodes of IE were included, 2113 from SE and 2082 from NCE; 2787 cases were included between 2000 and 2006 and 1408 between 2008 and 2012. Median (IQR) age was 62023-01-01T00:00:00Z2023 Apr2025-04-05T10:55:11.717Z2025-02-18T23:26:14.287ZS-EPMC101478763692246010.1007/s40121-023-00763-8