biostudies-literatureUnknown13(1)Flaus A<h4>Background</h4>To show the equivalence between the specific binding ratios (SBR) of visually normal ¹²³I-FP-CIT SPECT scans from patients to those from healthy volunteers (Hv) or patients without dopaminergic degeneration to allow their use as a reference database.<h4>Methods</h4>The SBR values of visually normal SPECT scans from 3 groups were studied: (1) suspected Parkinsonism and no diagnostic follow-up (ScanOnlyDB: n = 764, NM/CT 670 CZT, GE Healthcare), (2) no degenerative dopaminergic pathology after a 5-year follow-up (NoDG5YearsDB: n = 237, Symbia T2, Siemens Medical Solutions), and 3) Hv (HvDB: n = 118, commercial GE database). A general linear model (GLM) was constructed with caudate, putamen, and striatum SBR as the dependent variables, and age and gender as the iEJNMMI research37https://www.ebi.ac.uk/biostudies/studies/S-EPMC10147889biostudies-literatureSemi-quantitative analysis of visually normal ¹²³I-FP-CIT across three large databases revealed no difference between control and patients.PMC10147889Philippe RScheiber CJanier MFlaus AThobois SfalseSemi-quantitative analysis of visually normal ¹²³I-FP-CIT across three large databases revealed no difference between control and patients.<h4>Background</h4>To show the equivalence between the specific binding ratios (SBR) of visually normal ¹²³I-FP-CIT SPECT scans from patients to those from healthy volunteers (Hv) or patients without dopaminergic degeneration to allow their use as a reference database.<h4>Methods</h4>The SBR values of visually normal SPECT scans from 3 groups were studied: (1) suspected Parkinsonism and no diagnostic follow-up (ScanOnlyDB: n = 764, NM/CT 670 CZT, GE Healthcare), (2) no degenerative dopaminergic pathology after a 5-year follow-up (NoDG5YearsDB: n = 237, Symbia T2, Siemens Medical Solutions), and 3) Hv (HvDB: n = 118, commercial GE database). A general linear model (GLM) was constructed with caudate, putamen, and striatum SBR as the dependent variables, and age and gender as the i2023-01-01T00:00:00Z2023 Apr2025-05-29T20:47:48.1Z2024-11-07T08:48:48.252ZS-EPMC101478893711795110.1186/s13550-023-00983-6