{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goldstein DJ"],"funding":["NHLBI","NHLBI NIH HHS"],"pagination":["1782-1792.e5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10148927"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["167(5)"],"pubmed_abstract":["Background
Diffuse intimal hyperplasia and graft irregularity adversely affect the long-term patency of saphenous vein grafts (SVGs) and clinical outcomes of patients undergoing coronary artery bypass grafting (CABG). The VEST trial evaluated the efficacy of external graft support in limiting the development of intimal hyperplasia (IH) at 1 year postsurgery. In the present secondary analysis, we explored the associations between graft disease and IH and clinical events. We also examined risk factors for early graft occlusion.Methods
VEST is a within-patient randomized, multicenter trial that enrolled 224 patients with multivessel coronary disease undergoing CABG surgery, of whom 203 were evaluated by 1 year postsurgery. Intimal hyperplasia, lumen uniformity, graft stenosis,"],"journal":["The Journal of thoracic and cardiovascular surgery"],"pubmed_title":["Intimal hyperplasia, saphenous vein graft disease, and clinical outcomes: Insights from the CTSN VEST randomized trial."],"pmcid":["PMC10148927"],"funding_grant_id":["U01 HL088942"],"pubmed_authors":["Gelijns AC","Iribarne A","Scavo V","Gillinov M","O'Sullivan K","Marks ME","Raymond S","Mack MJ","DiMaio JM","Goldstein DJ","Puskas JD","Acker MA","Alexander JH","Moquete EG","Crestanello JA","O'Gara PT","Bagiella E","Moskowitz AJ","Dagenais F","Voisine P","Chang HL","Narula J","Williams JB","Gammie JS","Vengrenyuk Y","Taylor BS","Ailawadi G","Chu MWA"],"additional_accession":[]},"is_claimable":false,"name":"Intimal hyperplasia, saphenous vein graft disease, and clinical outcomes: Insights from the CTSN VEST randomized trial.","description":"Background
Diffuse intimal hyperplasia and graft irregularity adversely affect the long-term patency of saphenous vein grafts (SVGs) and clinical outcomes of patients undergoing coronary artery bypass grafting (CABG). The VEST trial evaluated the efficacy of external graft support in limiting the development of intimal hyperplasia (IH) at 1 year postsurgery. In the present secondary analysis, we explored the associations between graft disease and IH and clinical events. We also examined risk factors for early graft occlusion.Methods
VEST is a within-patient randomized, multicenter trial that enrolled 224 patients with multivessel coronary disease undergoing CABG surgery, of whom 203 were evaluated by 1 year postsurgery. Intimal hyperplasia, lumen uniformity, graft stenosis,","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T20:58:23.264Z","creation":"2025-06-25T03:06:22.396Z"},"accession":"S-EPMC10148927","cross_references":{"pubmed":["36494209"],"doi":["10.1016/j.jtcvs.2022.10.034"]}}