{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brennan PA"],"funding":["NCATS NIH HHS","NIH Office of the Director","NIEHS NIH HHS","NIH HHS"],"pagination":["513-527"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10150657"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(4)"],"pubmed_abstract":["Prenatal antidepressant exposure has been associated with increased risk for neurodevelopmental disorders in childhood, including autism spectrum disorder (ASD). The current study utilized multi-cohort data from the Environmental influences on Child Health Outcomes (ECHO) program (N = 3129) to test for this association, and determine whether the association remained after adjusting for maternal prenatal depression and other potential confounders. Antidepressants and a subset of selective serotonin reuptake inhibitors (SSRIs) were examined in relation to binary (e.g., diagnostic) and continuous measures of ASD and ASD related traits (e.g., social difficulties, behavior problems) in children 1.5 to 12 years of age. Child sex was tested as an effect modifier. While prenatal antidepressant exp"],"journal":["Research on child and adolescent psychopathology"],"pubmed_title":["Prenatal Antidepressant Exposures and Autism Spectrum Disorder or Traits: A Retrospective, Multi-Cohort Study."],"pmcid":["PMC10150657"],"funding_grant_id":["UH3OD023318","UG3 OD023318","UH3OD023313","UH3OD023279","R24 ES029490","UH3OD023272","UH3OD023271","UL1 TR002538","UH3 OD023337","U2C OD023375","U24 OD023382","UH3OD023328","UH3OD023249","UH3OD023244","UH3OD023365","UH3OD023320","UH3OD023286","UH3OD023285","U2COD023375","UH3OD023282","UH3 OD023285","UH3 OD023282","UH3 OD023365","UH3 OD023244","UH3 OD023320","UH3 OD023286","UH3 OD023249","UH3 OD023328","UH3OD023337","U24 OD023319","UH3 OD023272","UH3 OD023271","UH3 OD023313","UH3 OD023279","U24OD023382","UH3 OD023318","UH3OD023305","UH3OD023349","UG3 OD023249","U24OD023319","UH3OD023347","UG3 OD023320","UH3OD023342","UG3 OD023285","UG3 OD023282","UH3 OD023342","UH3 OD023347","UH3 OD023305","UH3 OD023349"],"pubmed_authors":["Brennan PA","O'Connor TG","Hipwell AE","Mansolf M","Huddleston KC","Dunlop AL","Elliott AJ","Lin PD","Musci R","Croen LA","Li M","Lester BM","Sathyanarayana S","Li X","Ghildayal N","Avalos LA","Bendixsen C","Shuster CL","Salisbury AL","Crum RM","Sprowles JLN","Stanford JB","Ozonoff S","Posner J","Nozadi SS","Paneth N"],"additional_accession":[]},"is_claimable":false,"name":"Prenatal Antidepressant Exposures and Autism Spectrum Disorder or Traits: A Retrospective, Multi-Cohort Study.","description":"Prenatal antidepressant exposure has been associated with increased risk for neurodevelopmental disorders in childhood, including autism spectrum disorder (ASD). The current study utilized multi-cohort data from the Environmental influences on Child Health Outcomes (ECHO) program (N = 3129) to test for this association, and determine whether the association remained after adjusting for maternal prenatal depression and other potential confounders. Antidepressants and a subset of selective serotonin reuptake inhibitors (SSRIs) were examined in relation to binary (e.g., diagnostic) and continuous measures of ASD and ASD related traits (e.g., social difficulties, behavior problems) in children 1.5 to 12 years of age. Child sex was tested as an effect modifier. While prenatal antidepressant exp","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-04T20:15:23.14Z","creation":"2025-04-04T20:15:23.14Z"},"accession":"S-EPMC10150657","cross_references":{"pubmed":["36417100"],"doi":["10.1007/s10802-022-01000-5"]}}