{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Natov PS"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["e009776"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10150783"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(3)"],"pubmed_abstract":["<h4>Background</h4>Improvement in renal function (IRF) in acute decompensated heart failure is associated with adverse outcomes. The mechanisms driving this paradox remain undefined.<h4>Methods</h4>Using the ROSE-AHF study (Renal Optimization Strategies Evaluation-Acute Heart Failure), 277 patients were grouped according to renal function, with IRF defined by a ≥20% increase (N=75), worsening renal function by a ≥20% decline (N=53), and stable renal function (SRF) by a <20% change (N=149) in estimated glomerular filtration rate between baseline and 72 hours. Three well-validated renal tubular injury markers, NGAL (neutrophil gelatinase-associated lipocalin), NAG (N-acetyl-β-d-glucosaminidase), and KIM-1 (kidney injury molecule 1), were evaluated at baseline and 72 hours. Patients were also"],"journal":["Circulation. Heart failure"],"pubmed_title":["Improvement in Renal Function During the Treatment of Acute Decompensated Heart Failure: Relationship With Markers of Renal Tubular Injury and Prognostic Importance."],"pmcid":["PMC10150783"],"funding_grant_id":["R01 HL128973","R01 DK130997","R01 HL128526","R01 HL148354","U01 HL160226","R01 DK130870","R01 HL139629"],"pubmed_authors":["Cox ZL","Estrella MM","Ivey-Miranda JB","Shlipak MG","Moreno-Villagomez J","Bellumkonda L","Natov PS","Maulion C","Rao VS","Borlaug BA","Testani JM"],"additional_accession":[]},"is_claimable":false,"name":"Improvement in Renal Function During the Treatment of Acute Decompensated Heart Failure: Relationship With Markers of Renal Tubular Injury and Prognostic Importance.","description":"<h4>Background</h4>Improvement in renal function (IRF) in acute decompensated heart failure is associated with adverse outcomes. The mechanisms driving this paradox remain undefined.<h4>Methods</h4>Using the ROSE-AHF study (Renal Optimization Strategies Evaluation-Acute Heart Failure), 277 patients were grouped according to renal function, with IRF defined by a ≥20% increase (N=75), worsening renal function by a ≥20% decline (N=53), and stable renal function (SRF) by a <20% change (N=149) in estimated glomerular filtration rate between baseline and 72 hours. Three well-validated renal tubular injury markers, NGAL (neutrophil gelatinase-associated lipocalin), NAG (N-acetyl-β-d-glucosaminidase), and KIM-1 (kidney injury molecule 1), were evaluated at baseline and 72 hours. Patients were also","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-03T23:49:50.919Z","creation":"2025-04-03T23:49:50.919Z"},"accession":"S-EPMC10150783","cross_references":{"pubmed":["36700431"],"doi":["10.1161/CIRCHEARTFAILURE.122.009776","10.1161/circheartfailure.122.009776"]}}