biostudies-literatureNatov PSNIDDK NIH HHSNHLBI NIH HHSe009776https://www.ebi.ac.uk/biostudies/studies/S-EPMC10150783biostudies-literatureUnknown16(3)<h4>Background</h4>Improvement in renal function (IRF) in acute decompensated heart failure is associated with adverse outcomes. The mechanisms driving this paradox remain undefined.<h4>Methods</h4>Using the ROSE-AHF study (Renal Optimization Strategies Evaluation-Acute Heart Failure), 277 patients were grouped according to renal function, with IRF defined by a ≥20% increase (N=75), worsening renal function by a ≥20% decline (N=53), and stable renal function (SRF) by a <20% change (N=149) in estimated glomerular filtration rate between baseline and 72 hours. Three well-validated renal tubular injury markers, NGAL (neutrophil gelatinase-associated lipocalin), NAG (N-acetyl-β-d-glucosaminidase), and KIM-1 (kidney injury molecule 1), were evaluated at baseline and 72 hours. Patients were alsoCirculation. Heart failureImprovement in Renal Function During the Treatment of Acute Decompensated Heart Failure: Relationship With Markers of Renal Tubular Injury and Prognostic Importance.PMC10150783R01 HL128973R01 DK130997R01 HL128526R01 HL148354U01 HL160226R01 DK130870R01 HL139629Cox ZLEstrella MMIvey-Miranda JBShlipak MGMoreno-Villagomez JBellumkonda LNatov PSMaulion CRao VSBorlaug BATestani JMfalseImprovement in Renal Function During the Treatment of Acute Decompensated Heart Failure: Relationship With Markers of Renal Tubular Injury and Prognostic Importance.<h4>Background</h4>Improvement in renal function (IRF) in acute decompensated heart failure is associated with adverse outcomes. The mechanisms driving this paradox remain undefined.<h4>Methods</h4>Using the ROSE-AHF study (Renal Optimization Strategies Evaluation-Acute Heart Failure), 277 patients were grouped according to renal function, with IRF defined by a ≥20% increase (N=75), worsening renal function by a ≥20% decline (N=53), and stable renal function (SRF) by a <20% change (N=149) in estimated glomerular filtration rate between baseline and 72 hours. Three well-validated renal tubular injury markers, NGAL (neutrophil gelatinase-associated lipocalin), NAG (N-acetyl-β-d-glucosaminidase), and KIM-1 (kidney injury molecule 1), were evaluated at baseline and 72 hours. Patients were also2023-01-01T00:00:00Z2023 Mar2025-04-03T23:49:50.919Z2025-04-03T23:49:50.919ZS-EPMC101507833670043110.1161/CIRCHEARTFAILURE.122.00977610.1161/circheartfailure.122.009776