{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Berendzen KM"],"funding":["NIA NIH HHS","NIMH NIH HHS"],"pagination":["787-796.e4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10150797"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111(6)"],"pubmed_abstract":["Prairie voles are among a small group of mammals that display long-term social attachment between mating partners. Many pharmacological studies show that signaling via the oxytocin receptor (Oxtr) is critical for the display of social monogamy in these animals. We used CRISPR mutagenesis to generate three different Oxtr-null mutant prairie vole lines. Oxtr mutants displayed social attachment such that males and females showed a behavioral preference for their mating partners over a stranger of the opposite sex, even when assayed using different experimental setups. Mothers lacking Oxtr delivered viable pups, and parents displayed care for their young and raised them to the weanling stage. Together, our studies unexpectedly reveal that social attachment, parturition, and parental behavior can occur in the absence of Oxtr signaling in prairie voles."],"journal":["Neuron"],"pubmed_title":["Oxytocin receptor is not required for social attachment in prairie voles."],"pmcid":["PMC10150797"],"funding_grant_id":["K08 MH107754","R01 MH108319","P30 AG062422","DP1 MH099900","R01 MH123513","R25 MH060482"],"pubmed_authors":["Shah NM","Bond JM","Simmons TC","Sharma R","Rogers FD","Espineda I","Wei Y","Sherman M","Seelke AMH","Beery A","Mandujano MA","Parthasarthy S","Knoedler JR","Berendzen KM","Larios R","Goodwin NL","Manoli DS","Bales KL"],"additional_accession":[]},"is_claimable":false,"name":"Oxytocin receptor is not required for social attachment in prairie voles.","description":"Prairie voles are among a small group of mammals that display long-term social attachment between mating partners. Many pharmacological studies show that signaling via the oxytocin receptor (Oxtr) is critical for the display of social monogamy in these animals. We used CRISPR mutagenesis to generate three different Oxtr-null mutant prairie vole lines. Oxtr mutants displayed social attachment such that males and females showed a behavioral preference for their mating partners over a stranger of the opposite sex, even when assayed using different experimental setups. Mothers lacking Oxtr delivered viable pups, and parents displayed care for their young and raised them to the weanling stage. Together, our studies unexpectedly reveal that social attachment, parturition, and parental behavior can occur in the absence of Oxtr signaling in prairie voles.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-03T23:51:23.056Z","creation":"2025-04-03T23:51:23.056Z"},"accession":"S-EPMC10150797","cross_references":{"pubmed":["36708707"],"doi":["10.1016/j.neuron.2022.12.011"]}}