biostudies-literatureLi XPriority Academic Program Development of Jiangsu Higher Education Institutions1459-1475https://www.ebi.ac.uk/biostudies/studies/S-EPMC10152237biostudies-literatureUnknown83(9)Emerging evidence has demonstrated that circular RNAs (circRNA) are involved in cancer metastasis. Further elucidation of the role of circRNAs in oral squamous cell carcinoma (OSCC) could provide insights into mechanisms driving metastasis and potential therapeutic targets. Here, we identify a circRNA, circFNDC3B, that is significantly upregulated in OSCC and is positively associated with lymph node (LN) metastasis. In vitro and in vivo functional assays showed that circFNDC3B accelerated the migration and invasion of OSCC cells and the tube-forming capacity of human umbilical vein endothelial cells and human lymphatic endothelial cells. Mechanistically, circFNDC3B regulated ubiquitylation of the RNA-binding protein FUS and the deubiquitylation of HIF1A through the E3 ligase MDM2 to promotCancer researchcircFNDC3B Accelerates Vasculature Formation and Metastasis in Oral Squamous Cell Carcinoma.PMC10152237PAPD2018-80Li XLi YLiu LWang CXu RZhang HJiang HHou DFu YLiu DCheng JYe JfalsecircFNDC3B Accelerates Vasculature Formation and Metastasis in Oral Squamous Cell Carcinoma.Emerging evidence has demonstrated that circular RNAs (circRNA) are involved in cancer metastasis. Further elucidation of the role of circRNAs in oral squamous cell carcinoma (OSCC) could provide insights into mechanisms driving metastasis and potential therapeutic targets. Here, we identify a circRNA, circFNDC3B, that is significantly upregulated in OSCC and is positively associated with lymph node (LN) metastasis. In vitro and in vivo functional assays showed that circFNDC3B accelerated the migration and invasion of OSCC cells and the tube-forming capacity of human umbilical vein endothelial cells and human lymphatic endothelial cells. Mechanistically, circFNDC3B regulated ubiquitylation of the RNA-binding protein FUS and the deubiquitylation of HIF1A through the E3 ligase MDM2 to promot2023-01-01T00:00:00Z2023 May2026-05-28T11:50:22.603Z2025-04-07T03:18:47.929ZS-EPMC101522373681195710.1158/0008-5472.CAN-22-2585