biostudies-literatureUnknownGarbincius JFNIA NIH HHSNHLBI NIH HHSNINDS NIH HHS<h4>Background</h4>Mitochondrial calcium (_mCa²⁺) uptake through the mitochondrial calcium uniporter channel (mtCU) stimulates metabolism to meet acute increases in cardiac energy demand. However, excessive _mCa²⁺ uptake during stress, as in ischemia-reperfusion, initiates permeability transition and cell death. Despite these often-reported acute physiological and pathological effects, a major unresolved controversy is whether mtCU-dependent _mCa²⁺ uptake and long-term elevation of cardiomyocyte _mCa²⁺ contributes to the heart's adaptation during sustained increases in workload.<h4>Objective</h4>We tested the hypothesis that mtCU-dependent _mCa²⁺ uptake contributes to cardiac adaptationbioRxiv : the preprint server for biology2023.04.17.537222https://www.ebi.ac.uk/biostudies/studies/S-EPMC10153142biostudies-literatureMCU gain- and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure.PMC10153142P01 HL147841R01 HL123966F32 HL151146T32 HL091804R00 AG065445R01 HL142271P01 HL134608R01 HL136954RF1 NS121379Garbincius JFElrod JWLambert JPMangold ASMurray EKJadiya PLuongo TSHildebrand ANfalseMCU gain- and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure.<h4>Background</h4>Mitochondrial calcium (_mCa²⁺) uptake through the mitochondrial calcium uniporter channel (mtCU) stimulates metabolism to meet acute increases in cardiac energy demand. However, excessive _mCa²⁺ uptake during stress, as in ischemia-reperfusion, initiates permeability transition and cell death. Despite these often-reported acute physiological and pathological effects, a major unresolved controversy is whether mtCU-dependent _mCa²⁺ uptake and long-term elevation of cardiomyocyte _mCa²⁺ contributes to the heart's adaptation during sustained increases in workload.<h4>Objective</h4>We tested the hypothesis that mtCU-dependent _mCa²⁺ uptake contributes to cardiac adaptation2023-01-01T00:00:00Z2023 Apr2026-05-10T03:08:24.701Z2025-04-05T21:09:17.432ZS-EPMC101531423713181910.1101/2023.04.17.537222