{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu Y"],"funding":["Swiss National Science Foundation","European Research Council"],"pagination":["380-390"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10154232"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(4)"],"pubmed_abstract":["Neural stem cells (NSCs) generate new neurons throughout life in the mammalian hippocampus<sup>1</sup>. Advancing age leads to a decline in neurogenesis, which is associated with impaired cognition<sup>2,3</sup>. The cellular mechanisms causing reduced neurogenesis with advancing age remain largely unknown. We genetically labeled NSCs through conditional recombination driven by the regulatory elements of the stem-cell-expressed gene GLI family zinc finger 1 (Gli1) and used chronic intravital imaging to follow individual NSCs and their daughter cells over months within their hippocampal niche<sup>4,5</sup>. We show that aging affects multiple steps, from cell cycle entry of quiescent NSCs to determination of the number of surviving cells, ultimately causing reduced clonal output of individu"],"journal":["Nature aging"],"pubmed_title":["Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus."],"pmcid":["PMC10154232"],"funding_grant_id":["209272","157859"],"pubmed_authors":["Zehnder C","Fisch R","Helmchen F","Pilz GA","Simons BD","Bottes S","Wu Y","Cole JD","Jessberger S"],"additional_accession":[]},"is_claimable":false,"name":"Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus.","description":"Neural stem cells (NSCs) generate new neurons throughout life in the mammalian hippocampus<sup>1</sup>. Advancing age leads to a decline in neurogenesis, which is associated with impaired cognition<sup>2,3</sup>. The cellular mechanisms causing reduced neurogenesis with advancing age remain largely unknown. We genetically labeled NSCs through conditional recombination driven by the regulatory elements of the stem-cell-expressed gene GLI family zinc finger 1 (Gli1) and used chronic intravital imaging to follow individual NSCs and their daughter cells over months within their hippocampal niche<sup>4,5</sup>. We show that aging affects multiple steps, from cell cycle entry of quiescent NSCs to determination of the number of surviving cells, ultimately causing reduced clonal output of individu","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-21T22:48:16.72Z","creation":"2025-04-05T18:55:57.74Z"},"accession":"S-EPMC10154232","cross_references":{"pubmed":["37117787"],"doi":["10.1038/s43587-023-00370-9"]}}