{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Belhart K"],"funding":["Consejo Nacional de Investigaciones Científicas y Técnicas","International Union of Biochemestry and Molecular Biology","LSU Health Shreveport","Center of Excellence for Arthritis and Rheumatology","Universidad Nacional de La Plata","Universidad Nacional de La Plata,Argentina","Agencia Nacional de Promoción Científica y Tecnológica","Louisiana Board of Regents","National Institutes of Health","NIH HHS"],"pagination":["7157"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10154355"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Bordetella bronchiseptica is a gram-negative bacterium that causes respiratory diseases in different animals, including mice, making B. bronchiseptica the gold-standard model to investigate host-pathogen interaction at the molecular level. B. bronchiseptica utilizes many different mechanisms to precisely regulate the expression of virulence factors. Cyclic di-GMP is a second messenger synthesized by diguanylate cyclases and degraded by phosphodiesterases that regulates the expression of multiple virulence factors including biofilm formation. As in other bacteria, we have previously shown that c-di-GMP regulates motility and biofilm formation in B. bronchiseptica. This work describes the diguanylate cyclase BdcB (Bordetella diguanylate cyclase B) as an active diguanylate cyclase that promot"],"journal":["Scientific reports"],"pubmed_title":["Bordetella bronchiseptica diguanylate cyclase BdcB inhibits the type three secretion system and impacts the immune response."],"pmcid":["PMC10154355"],"funding_grant_id":["NIH COBRE award 1P20-GM134974-0181","PID-UNLP-X819","Research Career","IUBMB Wood-Whelan Research Fellowship","LEQSF(2022-25)-RD-A-33","Research Fellowship","PICT-2019-00680","Intramural Research Council Seed package support","intramural award"],"pubmed_authors":["Sisti F","Gestal MC","Fernandez J","Belhart K"],"additional_accession":[]},"is_claimable":false,"name":"Bordetella bronchiseptica diguanylate cyclase BdcB inhibits the type three secretion system and impacts the immune response.","description":"Bordetella bronchiseptica is a gram-negative bacterium that causes respiratory diseases in different animals, including mice, making B. bronchiseptica the gold-standard model to investigate host-pathogen interaction at the molecular level. B. bronchiseptica utilizes many different mechanisms to precisely regulate the expression of virulence factors. Cyclic di-GMP is a second messenger synthesized by diguanylate cyclases and degraded by phosphodiesterases that regulates the expression of multiple virulence factors including biofilm formation. As in other bacteria, we have previously shown that c-di-GMP regulates motility and biofilm formation in B. bronchiseptica. This work describes the diguanylate cyclase BdcB (Bordetella diguanylate cyclase B) as an active diguanylate cyclase that promot","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-05T00:11:49.561Z","creation":"2025-04-05T00:11:49.561Z"},"accession":"S-EPMC10154355","cross_references":{"pubmed":["37130958"],"doi":["10.1038/s41598-023-34106-x"]}}