biostudies-literatureNg HKNational Natural Science Foundation of Chinae13120https://www.ebi.ac.uk/biostudies/studies/S-EPMC10154375biostudies-literatureUnknown33(3)Recurrence is a major complication of some meningiomas. Although there were many studies on biomarkers associated with higher grades or increased aggressiveness, few studies specifically examined longitudinal samples of primary meningiomas and recurrences from the same patients for molecular life history. We studied 99 primary and recurrent meningiomas from 42 patients by FISH for 22q, 1q, 1p, 3p, 5q, 6q, 10p, 10q, 14q, 18q, CDKN2A/B homozygous deletion, ALT (Alternative Lengthening of Telomere), TERT re-arrangement, targeted sequencing and TERTp sequencing. Although NF2 mutation and 22q were well known to be aetiological events in meningiomas, we found that in these paired meningiomas, combining the two events resulted in an NF2/22q group (57 tumors from 25 patients) which were almost mutBrain pathology (Zurich, Switzerland)Molecular landscapes of longitudinal NF2/22q and non-NF2/22q meningiomas show different life histories.PMC1015437582072020Ng HKPoon MFWong QHShi ZFPoon WSChung NYChen HLi KKChan DTKwan JSMao YChan JYfalseMolecular landscapes of longitudinal NF2/22q and non-NF2/22q meningiomas show different life histories.Recurrence is a major complication of some meningiomas. Although there were many studies on biomarkers associated with higher grades or increased aggressiveness, few studies specifically examined longitudinal samples of primary meningiomas and recurrences from the same patients for molecular life history. We studied 99 primary and recurrent meningiomas from 42 patients by FISH for 22q, 1q, 1p, 3p, 5q, 6q, 10p, 10q, 14q, 18q, CDKN2A/B homozygous deletion, ALT (Alternative Lengthening of Telomere), TERT re-arrangement, targeted sequencing and TERTp sequencing. Although NF2 mutation and 22q were well known to be aetiological events in meningiomas, we found that in these paired meningiomas, combining the two events resulted in an NF2/22q group (57 tumors from 25 patients) which were almost mut2023-01-01T00:00:00Z2023 May2025-04-04T14:44:34.244Z2025-04-04T14:44:34.244ZS-EPMC101543753616740010.1111/bpa.13120