biostudies-literatureSklar ALNCRR NIH HHSNIMH NIH HHSNational Institutes of Health679-687https://www.ebi.ac.uk/biostudies/studies/S-EPMC10154701biostudies-literatureUnknown49(3)<h4>Background and hypothesis</h4>There is growing appreciation for the contribution of sensory disruptions to disease morbidity in psychosis. The present study examined auditory cortex (AC) dynamic range: the scaling of neurophysiological responses to stimulus intensity, among individuals with a schizophrenia spectrum illness (FESz) and its relationship to clinical outcomes at disease onset.<h4>Study design</h4>Magnetoencephalography (MEG) was recorded from 35 FESz and 40 healthy controls (HC) during binaural presentation of tones at three intensities (75 dB, 80 dB, and 85 dB). MRIs were obtained to enhance cortical localization of MEG sensor-level activity. All participants completed the MATRICS cognitive battery (MCCB) and Global Functioning: Role and Social scales (GFR/GFS). Patients wSchizophrenia bulletinDiminished Auditory Cortex Dynamic Range and its Clinical Correlates in First Episode Psychosis.PMC10154701T32 MH016804K23 MH1273895T32MH016804-40R01 MH108568UL1 RR024153Ren XCoffman BASklar ALChlpka LSalisbury DFCurtis MfalseDiminished Auditory Cortex Dynamic Range and its Clinical Correlates in First Episode Psychosis.<h4>Background and hypothesis</h4>There is growing appreciation for the contribution of sensory disruptions to disease morbidity in psychosis. The present study examined auditory cortex (AC) dynamic range: the scaling of neurophysiological responses to stimulus intensity, among individuals with a schizophrenia spectrum illness (FESz) and its relationship to clinical outcomes at disease onset.<h4>Study design</h4>Magnetoencephalography (MEG) was recorded from 35 FESz and 40 healthy controls (HC) during binaural presentation of tones at three intensities (75 dB, 80 dB, and 85 dB). MRIs were obtained to enhance cortical localization of MEG sensor-level activity. All participants completed the MATRICS cognitive battery (MCCB) and Global Functioning: Role and Social scales (GFR/GFS). Patients w2023-01-01T00:00:00Z2023 May2025-04-22T05:41:55.185Z2025-04-05T21:25:57.15ZS-EPMC101547013674931010.1093/schbul/sbac208