biostudies-literatureUnknown114(5)Natsuki STumor-resident memory T (T_RM ) cells in primary tumors are reportedly associated with a favorable prognosis in several malignancies. However, the behaviors and functions of T_RM cells in regional lymph nodes (LNs) of esophageal cancer remain poorly understood. The aim of this study was to elucidate the effects of T_RM cells in regional LNs of esophageal cancer on clinicopathological findings and prognosis. Specimens of esophageal cancer and primary metastatic LNs (recurrent nerve LNs) were obtained from 84 patients who underwent radical esophagectomy between 2011 and 2017. We performed immunohistochemistry to enumerate and analyze T_RM cells, and used flow cytometry to investigate the function of T_RM cells. T_RM cells were obserCancer science1846-1858https://www.ebi.ac.uk/biostudies/studies/S-EPMC10154829biostudies-literaturePrognostic relevance of tumor-resident memory T cells in metastatic lymph nodes of esophageal squamous cell carcinoma.PMC10154829Lee STanaka HDeguchi SToyokawa TNatsuki SNishiyama MMori TYoshii MMiki YTamura TMaeda KfalsePrognostic relevance of tumor-resident memory T cells in metastatic lymph nodes of esophageal squamous cell carcinoma.Tumor-resident memory T (T_RM ) cells in primary tumors are reportedly associated with a favorable prognosis in several malignancies. However, the behaviors and functions of T_RM cells in regional lymph nodes (LNs) of esophageal cancer remain poorly understood. The aim of this study was to elucidate the effects of T_RM cells in regional LNs of esophageal cancer on clinicopathological findings and prognosis. Specimens of esophageal cancer and primary metastatic LNs (recurrent nerve LNs) were obtained from 84 patients who underwent radical esophagectomy between 2011 and 2017. We performed immunohistochemistry to enumerate and analyze T_RM cells, and used flow cytometry to investigate the function of T_RM cells. T_RM cells were obser2023-01-01T00:00:00Z2023 May2026-06-28T03:15:26.01Z2025-04-04T11:14:06.638ZS-EPMC101548293674831110.1111/cas.15750