{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iguchi K"],"funding":["Yasuda Memorial Foundation","Science and Technology Platform Program for Advanced Biological Medicine from the Japan Agency for Medical Research and development, AMED","Ichiro Kanehara Foundation of the Promotion of Medical Science and Medical Care","Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI)","Translational Research Program from the Japan Agency for Medical Research and development, AMED","Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan","Project for Cancer Research And Therapeutic Evolution (P-CREATE) from the Japan Agency for Medical Research and development, AMED"],"pagination":["2063-2077"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10154837"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["114(5)"],"pubmed_abstract":["Hepatocellular carcinoma (HCC) is the most prevalent malignant liver neoplasm. Despite the advances in diagnosis and treatment, the prognosis of HCC patients remains poor. Cytoskeleton-associated membrane protein 4 (CKAP4) is a receptor of the glycosylated secretory protein Dickkopf-1 (DKK1), and the DKK1-CKAP4 axis is activated in pancreatic, lung, and esophageal cancer cells. Expression of DKK1 and CKAP4 has been examined in HCC in independent studies that yielded contradictory results. In this study, the relationship between the DKK1-CKAP4 axis and HCC was comprehensively examined. In 412 HCC cases, patients whose tumors were positive for both DKK1 and CKAP4 had a poor prognosis compared to those who were positive for only one of these markers or negative for both. Deletion of either DK"],"journal":["Cancer science"],"pubmed_title":["DKK1-CKAP4 signal axis promotes hepatocellular carcinoma aggressiveness."],"pmcid":["PMC10154837"],"funding_grant_id":["22ym0126039h0002","16H06374","20K16330","18975691","21K07121","20cm0106152h0002","18cm0106132h0001","22am0401003h0004","18K06956","22K15511"],"pubmed_authors":["Matsumoto S","Akita M","Kikuchi A","Kimura H","Gon H","Sada R","Iguchi K","Zen Y","Fukumoto T"],"additional_accession":[]},"is_claimable":false,"name":"DKK1-CKAP4 signal axis promotes hepatocellular carcinoma aggressiveness.","description":"Hepatocellular carcinoma (HCC) is the most prevalent malignant liver neoplasm. Despite the advances in diagnosis and treatment, the prognosis of HCC patients remains poor. Cytoskeleton-associated membrane protein 4 (CKAP4) is a receptor of the glycosylated secretory protein Dickkopf-1 (DKK1), and the DKK1-CKAP4 axis is activated in pancreatic, lung, and esophageal cancer cells. Expression of DKK1 and CKAP4 has been examined in HCC in independent studies that yielded contradictory results. In this study, the relationship between the DKK1-CKAP4 axis and HCC was comprehensively examined. In 412 HCC cases, patients whose tumors were positive for both DKK1 and CKAP4 had a poor prognosis compared to those who were positive for only one of these markers or negative for both. Deletion of either DK","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-04T14:44:25.915Z","creation":"2025-04-04T14:44:25.915Z"},"accession":"S-EPMC10154837","cross_references":{"pubmed":["36718957"],"doi":["10.1111/cas.15743"]}}