{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(3)"],"submitter":["Tsunematsu M"],"pubmed_abstract":["<h4>Aim</h4>The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel inflammation-based biomarker, which has been associated with long-term outcomes in patients with hepatocellular carcinoma. We aimed to investigate whether the CALLY index can predict the prognosis for distal cholangiocarcinoma after pancreaticoduodenectomy.<h4>Methods</h4>The study comprised 143 patients who had undergone primary pancreaticoduodenectomy for distal cholangiocarcinoma between 2002 to 2019. The CALLY index was defined as (albumin × lymphocyte)/ (CRP × 10<sup>4</sup>). We investigated the association of CALLY index with disease-free survival and overall survival by univariate and multivariate analyses.<h4>Results</h4>Eighty-seven (61%) patients had a preoperative CALLY index <3.5. In multivariate analysis, obstructive jaundice drainage (<i>P</i> < .01), poorly differentiated tumor (<i>P</i> < .01), and CALLY index<3.5 (<i>P</i> = .02) were independent predictors of disease-free survival, while obstructive jaundice drainage (<i>P</i> < .01), poorly differentiated tumor (<i>P</i> < .01), and CALLY index <3.5 (<i>P</i> = .02) were independent predictors of overall survival.<h4>Conclusion</h4>The CALLY index may be an independent and significant indicator of poor long-term outcomes in patients with distal cholangiocarcinoma after pancreaticoduodenectomy, suggesting the importance of comprehensive assessment for inflammatory status."],"journal":["Annals of gastroenterological surgery"],"pagination":["503-511"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10154875"],"repository":["biostudies-literature"],"pubmed_title":["The impact of C-reactive protein-albumin-lymphocyte (CALLY) index on the prognosis of patients with distal cholangiocarcinoma following pancreaticoduodenectomy."],"pmcid":["PMC10154875"],"pubmed_authors":["Yanagaki M","Furukawa K","Onda S","Uwagawa T","Usuba T","Tanji Y","Taniai T","Ikegami T","Shirai Y","Nakabayashi Y","Tsunematsu M","Haruki K","Okamoto T"],"additional_accession":[]},"is_claimable":false,"name":"The impact of C-reactive protein-albumin-lymphocyte (CALLY) index on the prognosis of patients with distal cholangiocarcinoma following pancreaticoduodenectomy.","description":"<h4>Aim</h4>The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel inflammation-based biomarker, which has been associated with long-term outcomes in patients with hepatocellular carcinoma. We aimed to investigate whether the CALLY index can predict the prognosis for distal cholangiocarcinoma after pancreaticoduodenectomy.<h4>Methods</h4>The study comprised 143 patients who had undergone primary pancreaticoduodenectomy for distal cholangiocarcinoma between 2002 to 2019. The CALLY index was defined as (albumin × lymphocyte)/ (CRP × 10<sup>4</sup>). We investigated the association of CALLY index with disease-free survival and overall survival by univariate and multivariate analyses.<h4>Results</h4>Eighty-seven (61%) patients had a preoperative CALLY index <3.5. In multivariate analysis, obstructive jaundice drainage (<i>P</i> < .01), poorly differentiated tumor (<i>P</i> < .01), and CALLY index<3.5 (<i>P</i> = .02) were independent predictors of disease-free survival, while obstructive jaundice drainage (<i>P</i> < .01), poorly differentiated tumor (<i>P</i> < .01), and CALLY index <3.5 (<i>P</i> = .02) were independent predictors of overall survival.<h4>Conclusion</h4>The CALLY index may be an independent and significant indicator of poor long-term outcomes in patients with distal cholangiocarcinoma after pancreaticoduodenectomy, suggesting the importance of comprehensive assessment for inflammatory status.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-26T14:24:28.183Z","creation":"2025-04-06T14:36:54.878Z"},"accession":"S-EPMC10154875","cross_references":{"pubmed":["37152771"],"doi":["10.1002/ags3.12637"]}}