biostudies-literatureUnknown7(3)Tsunematsu M<h4>Aim</h4>The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel inflammation-based biomarker, which has been associated with long-term outcomes in patients with hepatocellular carcinoma. We aimed to investigate whether the CALLY index can predict the prognosis for distal cholangiocarcinoma after pancreaticoduodenectomy.<h4>Methods</h4>The study comprised 143 patients who had undergone primary pancreaticoduodenectomy for distal cholangiocarcinoma between 2002 to 2019. The CALLY index was defined as (albumin × lymphocyte)/ (CRP × 10⁴). We investigated the association of CALLY index with disease-free survival and overall survival by univariate and multivariate analyses.<h4>Results</h4>Eighty-seven (61%) patients had a preoperative CALLY index <3.5. In multivariate analysis, obstructive jaundice drainage (<i>P</i> < .01), poorly differentiated tumor (<i>P</i> < .01), and CALLY index<3.5 (<i>P</i> = .02) were independent predictors of disease-free survival, while obstructive jaundice drainage (<i>P</i> < .01), poorly differentiated tumor (<i>P</i> < .01), and CALLY index <3.5 (<i>P</i> = .02) were independent predictors of overall survival.<h4>Conclusion</h4>The CALLY index may be an independent and significant indicator of poor long-term outcomes in patients with distal cholangiocarcinoma after pancreaticoduodenectomy, suggesting the importance of comprehensive assessment for inflammatory status.Annals of gastroenterological surgery503-511https://www.ebi.ac.uk/biostudies/studies/S-EPMC10154875biostudies-literatureThe impact of C-reactive protein-albumin-lymphocyte (CALLY) index on the prognosis of patients with distal cholangiocarcinoma following pancreaticoduodenectomy.PMC10154875Yanagaki MFurukawa KOnda SUwagawa TUsuba TTanji YTaniai TIkegami TShirai YNakabayashi YTsunematsu MHaruki KOkamoto TfalseThe impact of C-reactive protein-albumin-lymphocyte (CALLY) index on the prognosis of patients with distal cholangiocarcinoma following pancreaticoduodenectomy.<h4>Aim</h4>The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel inflammation-based biomarker, which has been associated with long-term outcomes in patients with hepatocellular carcinoma. We aimed to investigate whether the CALLY index can predict the prognosis for distal cholangiocarcinoma after pancreaticoduodenectomy.<h4>Methods</h4>The study comprised 143 patients who had undergone primary pancreaticoduodenectomy for distal cholangiocarcinoma between 2002 to 2019. The CALLY index was defined as (albumin × lymphocyte)/ (CRP × 10⁴). We investigated the association of CALLY index with disease-free survival and overall survival by univariate and multivariate analyses.<h4>Results</h4>Eighty-seven (61%) patients had a preoperative CALLY index <3.5. In multivariate analysis, obstructive jaundice drainage (<i>P</i> < .01), poorly differentiated tumor (<i>P</i> < .01), and CALLY index<3.5 (<i>P</i> = .02) were independent predictors of disease-free survival, while obstructive jaundice drainage (<i>P</i> < .01), poorly differentiated tumor (<i>P</i> < .01), and CALLY index <3.5 (<i>P</i> = .02) were independent predictors of overall survival.<h4>Conclusion</h4>The CALLY index may be an independent and significant indicator of poor long-term outcomes in patients with distal cholangiocarcinoma after pancreaticoduodenectomy, suggesting the importance of comprehensive assessment for inflammatory status.2023-01-01T00:00:00Z2023 May2025-04-26T14:24:28.183Z2025-04-06T14:36:54.878ZS-EPMC101548753715277110.1002/ags3.12637