{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(5)"],"submitter":["Shaswati M"],"pubmed_abstract":["<h4>Background and aims</h4>Cervical cancer is characterized by abnormal cell growth in the lining of cervix and it is the second major cause of cancer-related deaths among females in Bangladesh. Interleukin-6 (<i>IL-6</i>) is a multifunctional cytokine that has been heavily linked with cervical cancer. Our aim was to investigate the association of two promoter single-nucleotide polymorphisms (SNPs) of <i>IL-6</i> (rs1800795 and rs1800797) with the susceptibility of cervical cancer in Bangladeshi women.<h4>Methods</h4>DNA was extracted from venous blood samples from cervical cancer patients (<i>n</i> = 126) and healthy controls (<i>n</i> = 120). Polymerase chain reaction-restriction fragment length polymorphism was used for genotyping of the selected SNPs. Logistic regression was performed"],"journal":["Health science reports"],"pagination":["e1238"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10155201"],"repository":["biostudies-literature"],"pubmed_title":["Polymorphisms of the interleukin-6 (<i>IL-6</i>) gene contribute to cervical cancer susceptibility in Bangladeshi women: A case-control study."],"pmcid":["PMC10155201"],"pubmed_authors":["Oeishy FH","Mumu SB","Mostaid MS","Reza HM","Shaswati M","Zahid MZI","Hossain M","Haque MA"],"additional_accession":[]},"is_claimable":false,"name":"Polymorphisms of the interleukin-6 (<i>IL-6</i>) gene contribute to cervical cancer susceptibility in Bangladeshi women: A case-control study.","description":"<h4>Background and aims</h4>Cervical cancer is characterized by abnormal cell growth in the lining of cervix and it is the second major cause of cancer-related deaths among females in Bangladesh. Interleukin-6 (<i>IL-6</i>) is a multifunctional cytokine that has been heavily linked with cervical cancer. Our aim was to investigate the association of two promoter single-nucleotide polymorphisms (SNPs) of <i>IL-6</i> (rs1800795 and rs1800797) with the susceptibility of cervical cancer in Bangladeshi women.<h4>Methods</h4>DNA was extracted from venous blood samples from cervical cancer patients (<i>n</i> = 126) and healthy controls (<i>n</i> = 120). Polymerase chain reaction-restriction fragment length polymorphism was used for genotyping of the selected SNPs. Logistic regression was performed","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-05-28T20:14:16.928Z","creation":"2025-02-19T04:29:00.593Z"},"accession":"S-EPMC10155201","cross_references":{"pubmed":["37152226"],"doi":["10.1002/hsr2.1238"]}}