biostudies-literatureUnknown6(5)Shaswati M<h4>Background and aims</h4>Cervical cancer is characterized by abnormal cell growth in the lining of cervix and it is the second major cause of cancer-related deaths among females in Bangladesh. Interleukin-6 (<i>IL-6</i>) is a multifunctional cytokine that has been heavily linked with cervical cancer. Our aim was to investigate the association of two promoter single-nucleotide polymorphisms (SNPs) of <i>IL-6</i> (rs1800795 and rs1800797) with the susceptibility of cervical cancer in Bangladeshi women.<h4>Methods</h4>DNA was extracted from venous blood samples from cervical cancer patients (<i>n</i> = 126) and healthy controls (<i>n</i> = 120). Polymerase chain reaction-restriction fragment length polymorphism was used for genotyping of the selected SNPs. Logistic regression was performedHealth science reportse1238https://www.ebi.ac.uk/biostudies/studies/S-EPMC10155201biostudies-literaturePolymorphisms of the interleukin-6 (<i>IL-6</i>) gene contribute to cervical cancer susceptibility in Bangladeshi women: A case-control study.PMC10155201Oeishy FHMumu SBMostaid MSReza HMShaswati MZahid MZIHossain MHaque MAfalsePolymorphisms of the interleukin-6 (<i>IL-6</i>) gene contribute to cervical cancer susceptibility in Bangladeshi women: A case-control study.<h4>Background and aims</h4>Cervical cancer is characterized by abnormal cell growth in the lining of cervix and it is the second major cause of cancer-related deaths among females in Bangladesh. Interleukin-6 (<i>IL-6</i>) is a multifunctional cytokine that has been heavily linked with cervical cancer. Our aim was to investigate the association of two promoter single-nucleotide polymorphisms (SNPs) of <i>IL-6</i> (rs1800795 and rs1800797) with the susceptibility of cervical cancer in Bangladeshi women.<h4>Methods</h4>DNA was extracted from venous blood samples from cervical cancer patients (<i>n</i> = 126) and healthy controls (<i>n</i> = 120). Polymerase chain reaction-restriction fragment length polymorphism was used for genotyping of the selected SNPs. Logistic regression was performed2023-01-01T00:00:00Z2023 May2026-05-28T20:14:16.928Z2025-02-19T04:29:00.593ZS-EPMC101552013715222610.1002/hsr2.1238