{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(7)"],"submitter":["Han X"],"pubmed_abstract":["<b>Background:</b> Currently, the prognosis and survival rate for patients bearing non-small cell lung cancer (NSCLC) is still quite poor, mainly due to lack of efficient theranostic paradigms to exert in time diagnostics and therapeutics. <b>Methods:</b> Herein, for NSCLC treatment, we offer a customized theranostic paradigm, termed NIR-IIb fluorescence diagnosis and synergistic surgery/starvation/chemodynamic therapeutics, with a newly designed theranostic nanoplatform PEG/MnCuDCNPs@GOx. The nanoplatform is composed of brightly NIR-II emissive downconversion nanoparticles (DCNPs)-core and Mn/Cu-silica shell loaded with glucose oxidase (GOx) to achieve synergistic starvation and chemodynamic therapy (CDT). <b>Results:</b> It is found that 10% Ce<sup>3+</sup> doped in the core and 100% Yb<sup>3+</sup> doped in the middle shell greatly improves the NIR-IIb emission up to even 20.3 times as compared to the core-shell DCNPs without Ce<sup>3+</sup> doping and middle shell. The bright NIR-IIb emission of the nanoplatform contributes to sensitive margin delineation of early-stage NSCLC (diameter < 1 mm) with a signal-to-background ratio (SBR) of 2.18, and further assists in visualizing drug distribution and guiding surgery/starvation/chemodynamic therapy. Notably, the starvation therapy mediated by GOx-driven oxidation reaction efficiently depletes intratumoral glucose, and supplies H<sub>2</sub>O<sub>2</sub> to boost the CDT mediated by the Mn<sup>2+</sup> and Cu<sup>2+</sup>, which consequently realized a highly effective synergistic treatment for NSCLC. <b>Conclusion:</b> This research demonstrates an efficient treatment paradigm for NSCLC with NIR-IIb fluorescence diganosis and image-guided synergistic surgery/starvation/chemodynamic therapeutics."],"journal":["Theranostics"],"pagination":["2176-2191"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10157733"],"repository":["biostudies-literature"],"pubmed_title":["NIR-IIb fluorescence-image guided synergistic surgery/starvation/chemodynamic therapy: an innovative treatment paradigm for malignant non-small cell lung cancers."],"pmcid":["PMC10157733"],"pubmed_authors":["Guo Z","Meng Q","Han X","Zhong Y","Chen H","Huang L","Feng C","Dai X","Lan Z","Ma C","He Z","Gu J","Mi C","Guo B","Zhang B"],"additional_accession":[]},"is_claimable":false,"name":"NIR-IIb fluorescence-image guided synergistic surgery/starvation/chemodynamic therapy: an innovative treatment paradigm for malignant non-small cell lung cancers.","description":"<b>Background:</b> Currently, the prognosis and survival rate for patients bearing non-small cell lung cancer (NSCLC) is still quite poor, mainly due to lack of efficient theranostic paradigms to exert in time diagnostics and therapeutics. <b>Methods:</b> Herein, for NSCLC treatment, we offer a customized theranostic paradigm, termed NIR-IIb fluorescence diagnosis and synergistic surgery/starvation/chemodynamic therapeutics, with a newly designed theranostic nanoplatform PEG/MnCuDCNPs@GOx. The nanoplatform is composed of brightly NIR-II emissive downconversion nanoparticles (DCNPs)-core and Mn/Cu-silica shell loaded with glucose oxidase (GOx) to achieve synergistic starvation and chemodynamic therapy (CDT). <b>Results:</b> It is found that 10% Ce<sup>3+</sup> doped in the core and 100% Yb<sup>3+</sup> doped in the middle shell greatly improves the NIR-IIb emission up to even 20.3 times as compared to the core-shell DCNPs without Ce<sup>3+</sup> doping and middle shell. The bright NIR-IIb emission of the nanoplatform contributes to sensitive margin delineation of early-stage NSCLC (diameter < 1 mm) with a signal-to-background ratio (SBR) of 2.18, and further assists in visualizing drug distribution and guiding surgery/starvation/chemodynamic therapy. Notably, the starvation therapy mediated by GOx-driven oxidation reaction efficiently depletes intratumoral glucose, and supplies H<sub>2</sub>O<sub>2</sub> to boost the CDT mediated by the Mn<sup>2+</sup> and Cu<sup>2+</sup>, which consequently realized a highly effective synergistic treatment for NSCLC. <b>Conclusion:</b> This research demonstrates an efficient treatment paradigm for NSCLC with NIR-IIb fluorescence diganosis and image-guided synergistic surgery/starvation/chemodynamic therapeutics.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-26T14:25:32.518Z","creation":"2025-04-06T14:37:07.855Z"},"accession":"S-EPMC10157733","cross_references":{"pubmed":["37153731"],"doi":["10.7150/thno.83753"]}}