biostudies-literatureMu YFundamental Research Funds for the Central Universities60https://www.ebi.ac.uk/biostudies/studies/S-EPMC10158360biostudies-literatureUnknown14(1)<h4>Background</h4>Bovine milk is an important source of nutrition for human consumption, and its quality is closely associated with the microbiota and metabolites in it. But there is limited knowledge about the milk microbiome and metabolome in cows with subacute ruminal acidosis.<h4>Methods</h4>Eight ruminally cannulated Holstein cows in mid lactation were selected for a 3-week experiment. The cows were randomly allocated into 2 groups, fed either a conventional diet (CON; 40% concentrate; dry matter basis) or a high-concentrate diet (HC; 60% concentrate; dry matter basis).<h4>Results</h4>The results showed that there was a decreased milk fat percentage in the HC group compared to the CON group. The amplicon sequencing results indicated that the alpha diversity indices were not affected Journal of animal science and biotechnologyCoordinated response of milk bacterial and metabolic profiles to subacute ruminal acidosis in lactating dairy cows.PMC10158360JCQY201905Zhang TMao SMu YZhang JQi WfalseCoordinated response of milk bacterial and metabolic profiles to subacute ruminal acidosis in lactating dairy cows.<h4>Background</h4>Bovine milk is an important source of nutrition for human consumption, and its quality is closely associated with the microbiota and metabolites in it. But there is limited knowledge about the milk microbiome and metabolome in cows with subacute ruminal acidosis.<h4>Methods</h4>Eight ruminally cannulated Holstein cows in mid lactation were selected for a 3-week experiment. The cows were randomly allocated into 2 groups, fed either a conventional diet (CON; 40% concentrate; dry matter basis) or a high-concentrate diet (HC; 60% concentrate; dry matter basis).<h4>Results</h4>The results showed that there was a decreased milk fat percentage in the HC group compared to the CON group. The amplicon sequencing results indicated that the alpha diversity indices were not affected 2023-01-01T00:00:00Z2023 May2025-04-04T14:44:29.39Z2025-04-04T14:44:29.39ZS-EPMC101583603713833010.1186/s40104-023-00859-8