{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gonczy P"],"funding":["Swiss Federal Institute of Technology Lausanne","NIH HHS"],"pagination":["iyad048"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10158834"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["224(1)"],"pubmed_abstract":["Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are contributed solely by the sperm to the zygote in most species. Centrioles can have a stereotyped distribution in some asymmetric divisions, but whether sperm-contributed centrioles are distributed in a stereotyped manner in the resulting embryo is not known. Here, we address this question in Caenorhabditis elegans using marked mating experiments, whereby the presence of the 2 sperm-contributed centrioles is monitored in the embryo using the stable centriolar component SAS-4::GFP, as well as GFP::SAS-7. Our analysis demonstrates that the distribution of sperm-contributed centri"],"journal":["Genetics"],"pubmed_title":["Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos."],"pmcid":["PMC10158834"],"funding_grant_id":["P40 OD010440"],"pubmed_authors":["Gonczy P","Balestra FR"],"additional_accession":[]},"is_claimable":false,"name":"Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos.","description":"Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are contributed solely by the sperm to the zygote in most species. Centrioles can have a stereotyped distribution in some asymmetric divisions, but whether sperm-contributed centrioles are distributed in a stereotyped manner in the resulting embryo is not known. Here, we address this question in Caenorhabditis elegans using marked mating experiments, whereby the presence of the 2 sperm-contributed centrioles is monitored in the embryo using the stable centriolar component SAS-4::GFP, as well as GFP::SAS-7. Our analysis demonstrates that the distribution of sperm-contributed centri","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-07-02T03:04:23.337Z","creation":"2025-04-05T00:11:40.342Z"},"accession":"S-EPMC10158834","cross_references":{"pubmed":["36988082"],"doi":["10.1093/genetics/iyad048"]}}