{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(5)"],"submitter":["Lin F"],"pubmed_abstract":["<h4>Objective</h4>Tirzeptide is a novel glucagon-like peptide-1 receptor (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) drug, which shows good efficiency for weight loss. Therefore, we aim to investigate the efficacy and safety of tirzepatide for weight loss in type 2 diabetes mellitus (T2DM) and obesity patients in this meta-analysis study.<h4>Methods</h4>Cochrane Library, PubMed, Embase, Clinical Trials, and Web of Science were searched from inception to October 5, 2022. All randomized controlled trials (RCTs) were included. The odds ratio (OR) was calculated using fixed-effects or random-effects models by Review Manager 5.3 software.<h4>Results</h4>In total, ten studies (12 reports) involving 9,873 patients were identified. A significant loss body weight in the tirzepati"],"journal":["PloS one"],"pagination":["e0285197"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10159347"],"repository":["biostudies-literature"],"pubmed_title":["Weight loss efficiency and safety of tirzepatide: A Systematic review."],"pmcid":["PMC10159347"],"pubmed_authors":["Li Y","Ling B","Yu B","Lv G","Chen J","Lin F","Shang H","Jie X","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"Weight loss efficiency and safety of tirzepatide: A Systematic review.","description":"<h4>Objective</h4>Tirzeptide is a novel glucagon-like peptide-1 receptor (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) drug, which shows good efficiency for weight loss. Therefore, we aim to investigate the efficacy and safety of tirzepatide for weight loss in type 2 diabetes mellitus (T2DM) and obesity patients in this meta-analysis study.<h4>Methods</h4>Cochrane Library, PubMed, Embase, Clinical Trials, and Web of Science were searched from inception to October 5, 2022. All randomized controlled trials (RCTs) were included. The odds ratio (OR) was calculated using fixed-effects or random-effects models by Review Manager 5.3 software.<h4>Results</h4>In total, ten studies (12 reports) involving 9,873 patients were identified. A significant loss body weight in the tirzepati","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-06-28T03:06:20.777Z","creation":"2025-04-06T18:49:08.686Z"},"accession":"S-EPMC10159347","cross_references":{"pubmed":["37141329"],"doi":["10.1371/journal.pone.0285197"]}}