{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Rathbun LA"],"pubmed_abstract":["The human Lymphocyte antigen-6 (<i>LY6</i>) gene family has recently gained interest for its possible role in tumor progression. We have carried out <i>in silico</i> analyses of all known <i>LY6</i> gene expression and amplification in different cancers using TNMplot and cBioportal. We also have analyzed patient survival by Kaplan-Meier plotter after mining the TCGA database. We report that upregulated expression of many <i>LY6</i> genes is associated with poor survival in uterine corpus endometrial carcinoma (UCEC) cancer patients. Importantly, the expression of several <i>LY6</i> genes is elevated in UCEC when compared to the expression in normal uterine tissue. For example, <i>LY6K</i> expression is 8.25× higher in UCEC compared to normal uterine tissue, and this high expression is associated with poor survival with a hazard ratio of 2.42 (<i>p</i>-value = 0.0032). Therefore, some <i>LY6</i> gene products may serve as tumor-associated antigens in UCEC, biomarkers for UCEC detection, and possibly targets for directing UCEC patient therapy. Further analysis of tumor-specific expression of <i>LY6</i> gene family members and LY6-triggered signaling pathways is needed to uncover the function of <i>LY6</i> proteins and their ability to endow tumor survival and poor prognosis in UCEC patients."],"journal":["Oncotarget"],"pagination":["426-437"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10159366"],"repository":["biostudies-literature"],"pubmed_title":["Human <i>LY6</i> gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma."],"pmcid":["PMC10159366"],"pubmed_authors":["Bamezai AK","Magliocco AM","Rathbun LA"],"additional_accession":[]},"is_claimable":false,"name":"Human <i>LY6</i> gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma.","description":"The human Lymphocyte antigen-6 (<i>LY6</i>) gene family has recently gained interest for its possible role in tumor progression. We have carried out <i>in silico</i> analyses of all known <i>LY6</i> gene expression and amplification in different cancers using TNMplot and cBioportal. We also have analyzed patient survival by Kaplan-Meier plotter after mining the TCGA database. We report that upregulated expression of many <i>LY6</i> genes is associated with poor survival in uterine corpus endometrial carcinoma (UCEC) cancer patients. Importantly, the expression of several <i>LY6</i> genes is elevated in UCEC when compared to the expression in normal uterine tissue. For example, <i>LY6K</i> expression is 8.25× higher in UCEC compared to normal uterine tissue, and this high expression is associated with poor survival with a hazard ratio of 2.42 (<i>p</i>-value = 0.0032). Therefore, some <i>LY6</i> gene products may serve as tumor-associated antigens in UCEC, biomarkers for UCEC detection, and possibly targets for directing UCEC patient therapy. Further analysis of tumor-specific expression of <i>LY6</i> gene family members and LY6-triggered signaling pathways is needed to uncover the function of <i>LY6</i> proteins and their ability to endow tumor survival and poor prognosis in UCEC patients.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-05-28T18:32:43.871Z","creation":"2025-02-19T04:29:14.254Z"},"accession":"S-EPMC10159366","cross_references":{"pubmed":["37141412"],"doi":["10.18632/oncotarget.28409"]}}