biostudies-literatureUnknown14Rathbun LAThe human Lymphocyte antigen-6 (<i>LY6</i>) gene family has recently gained interest for its possible role in tumor progression. We have carried out <i>in silico</i> analyses of all known <i>LY6</i> gene expression and amplification in different cancers using TNMplot and cBioportal. We also have analyzed patient survival by Kaplan-Meier plotter after mining the TCGA database. We report that upregulated expression of many <i>LY6</i> genes is associated with poor survival in uterine corpus endometrial carcinoma (UCEC) cancer patients. Importantly, the expression of several <i>LY6</i> genes is elevated in UCEC when compared to the expression in normal uterine tissue. For example, <i>LY6K</i> expression is 8.25× higher in UCEC compared to normal uterine tissue, and this high expression is associated with poor survival with a hazard ratio of 2.42 (<i>p</i>-value = 0.0032). Therefore, some <i>LY6</i> gene products may serve as tumor-associated antigens in UCEC, biomarkers for UCEC detection, and possibly targets for directing UCEC patient therapy. Further analysis of tumor-specific expression of <i>LY6</i> gene family members and LY6-triggered signaling pathways is needed to uncover the function of <i>LY6</i> proteins and their ability to endow tumor survival and poor prognosis in UCEC patients.Oncotarget426-437https://www.ebi.ac.uk/biostudies/studies/S-EPMC10159366biostudies-literatureHuman <i>LY6</i> gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma.PMC10159366Bamezai AKMagliocco AMRathbun LAfalseHuman <i>LY6</i> gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma.The human Lymphocyte antigen-6 (<i>LY6</i>) gene family has recently gained interest for its possible role in tumor progression. We have carried out <i>in silico</i> analyses of all known <i>LY6</i> gene expression and amplification in different cancers using TNMplot and cBioportal. We also have analyzed patient survival by Kaplan-Meier plotter after mining the TCGA database. We report that upregulated expression of many <i>LY6</i> genes is associated with poor survival in uterine corpus endometrial carcinoma (UCEC) cancer patients. Importantly, the expression of several <i>LY6</i> genes is elevated in UCEC when compared to the expression in normal uterine tissue. For example, <i>LY6K</i> expression is 8.25× higher in UCEC compared to normal uterine tissue, and this high expression is associated with poor survival with a hazard ratio of 2.42 (<i>p</i>-value = 0.0032). Therefore, some <i>LY6</i> gene products may serve as tumor-associated antigens in UCEC, biomarkers for UCEC detection, and possibly targets for directing UCEC patient therapy. Further analysis of tumor-specific expression of <i>LY6</i> gene family members and LY6-triggered signaling pathways is needed to uncover the function of <i>LY6</i> proteins and their ability to endow tumor survival and poor prognosis in UCEC patients.2023-01-01T00:00:00Z2023 May2026-05-28T18:32:43.871Z2025-02-19T04:29:14.254ZS-EPMC101593663714141210.18632/oncotarget.28409