{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gibson BA"],"funding":["Austrian Science Fund FWF","European Research Council","HHS | NIH | National Institute of General Medical Sciences","Howard Hughes Medical Institute","Wiener Wissenschafts-, Forschungs- und Technologiefonds","Paul G. Allen Frontiers Group","Welch Foundation","NIGMS NIH HHS","National Science Foundation"],"pagination":["e2218085120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10161002"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(18)"],"pubmed_abstract":["Nuclear DNA in eukaryotes is wrapped around histone proteins to form nucleosomes on a chromatin fiber. Dynamic folding of the chromatin fiber into loops and variations in the degree of chromatin compaction regulate essential processes such as transcription, recombination, and mitotic chromosome segregation. Our understanding of the physical properties that allow chromatin to be dynamically remodeled even in highly compacted states is limited. Previously, we reported that chromatin has an intrinsic capacity to phase separate and form dynamic liquid-like condensates, which can be regulated by cellular factors [B. A. Gibson <i>et al.</i>, <i>Cell</i> <b>179</b>, 470-484.e421 (2019)]. Recent contradictory reports claim that a specific set of solution conditions is required for fluidity in cond"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["In diverse conditions, intrinsic chromatin condensates have liquid-like material properties."],"pmcid":["PMC10161002"],"funding_grant_id":["F32 GM129925","NA","R35 GM141736","LS19-001","101019039","SFB F34-06","NSF-1921794","R35 GM127020","I-1544","F32GM129925","DK W1238","LS17-003"],"pubmed_authors":["Doolittle LK","Lou T","Chen L","Gibson BA","Narlikar GJ","Gerlich DW","Blaukopf C","Rosen MK","Finkelstein I"],"additional_accession":[]},"is_claimable":false,"name":"In diverse conditions, intrinsic chromatin condensates have liquid-like material properties.","description":"Nuclear DNA in eukaryotes is wrapped around histone proteins to form nucleosomes on a chromatin fiber. Dynamic folding of the chromatin fiber into loops and variations in the degree of chromatin compaction regulate essential processes such as transcription, recombination, and mitotic chromosome segregation. Our understanding of the physical properties that allow chromatin to be dynamically remodeled even in highly compacted states is limited. Previously, we reported that chromatin has an intrinsic capacity to phase separate and form dynamic liquid-like condensates, which can be regulated by cellular factors [B. A. Gibson <i>et al.</i>, <i>Cell</i> <b>179</b>, 470-484.e421 (2019)]. Recent contradictory reports claim that a specific set of solution conditions is required for fluidity in cond","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-05T16:12:17.999Z","creation":"2025-04-05T16:12:17.999Z"},"accession":"S-EPMC10161002","cross_references":{"pubmed":["37094140"],"doi":["10.1073/pnas.2218085120"]}}