biostudies-literatureGaio VEuropean Centre for Disease Prevention and Controle068996https://www.ebi.ac.uk/biostudies/studies/S-EPMC10163328biostudies-literatureUnknown13(5)<h4>Objectives</h4>Healthcare workers (HCWs) were the first to be prioritised for COVID-19 vaccination. This study aims to estimate the COVID-19 vaccine effectiveness (VE) against SARS-CoV-2 symptomatic infection among HCWs in Portuguese hospitals.<h4>Design</h4>Prospective cohort study.<h4>Setting and participants</h4>We analysed data from HCWs (all professional categories) from three central hospitals: one in the Lisbon and Tagus Valley region and two in the central region of mainland Portugal, between December 2020 and March 2022. VE against symptomatic SARS-CoV-2 infection was estimated as one minus the confounder adjusted HRs by Cox models considering age group, sex, self-reported chronic disease and occupational exposure to patients diagnosed with COVID-19 as adjustment variables.<h4BMJ openCOVID-19 vaccine effectiveness among healthcare workers: a hospital-based cohort study.PMC10163328ECD.12609ECD.12175ECD.11486Pacheco VSantos AJDias CGaio VAraujo LAntunes IFaro Viana JPaiva AAntunes Goncalves LKislaya IAmaral PSilva AMachado APinto Leite PNunes BfalseCOVID-19 vaccine effectiveness among healthcare workers: a hospital-based cohort study.<h4>Objectives</h4>Healthcare workers (HCWs) were the first to be prioritised for COVID-19 vaccination. This study aims to estimate the COVID-19 vaccine effectiveness (VE) against SARS-CoV-2 symptomatic infection among HCWs in Portuguese hospitals.<h4>Design</h4>Prospective cohort study.<h4>Setting and participants</h4>We analysed data from HCWs (all professional categories) from three central hospitals: one in the Lisbon and Tagus Valley region and two in the central region of mainland Portugal, between December 2020 and March 2022. VE against symptomatic SARS-CoV-2 infection was estimated as one minus the confounder adjusted HRs by Cox models considering age group, sex, self-reported chronic disease and occupational exposure to patients diagnosed with COVID-19 as adjustment variables.<h42023-01-01T00:00:00Z2023 May2025-04-22T00:30:36.01Z2025-04-05T19:36:15.512ZS-EPMC101633283713069210.1136/bmjopen-2022-068996