{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bernasek SM"],"funding":["Simons Foundation","Robert H. Lurie Comprehensive Cancer Center","NEI NIH HHS","Howard Hughes Medical Institute","National Institutes of Health","Chicago Biomedical Consortium","NIGMS NIH HHS","National Science Foundation"],"pagination":["dev201467"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10163347"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["150(8)"],"pubmed_abstract":["Cell state transitions are often triggered by large changes in the concentrations of transcription factors and therefore large differences in their stoichiometric ratios. Whether cells can elicit transitions using modest changes in the ratios of co-expressed factors is unclear. Here, we investigate how cells in the Drosophila eye resolve state transitions by quantifying the expression dynamics of the ETS transcription factors Pnt and Yan. Eye progenitor cells maintain a relatively constant ratio of Pnt/Yan protein, despite expressing both proteins with pulsatile dynamics. A rapid and sustained twofold increase in the Pnt/Yan ratio accompanies transitions to photoreceptor fates. Genetic perturbations that modestly disrupt the Pnt/Yan ratio produce fate transition defects consistent with the"],"journal":["Development (Cambridge, England)"],"pubmed_title":["Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila."],"pmcid":["PMC10163347"],"funding_grant_id":["EY025957","1764421","GM118144","597491","R01 GM080372","GM080372","R01 EY025957","R35 GM118144","EY032233","R21 EY032233"],"pubmed_authors":["Hur SSJ","Pelaez-Restrepo N","Sanchez-Luege N","Carthew RW","Bernasek SM","Amaral LAN","Boisclair Lachance JF","Rebay I","Navarro HT","Bakker R","Bagheri N"],"additional_accession":[]},"is_claimable":false,"name":"Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila.","description":"Cell state transitions are often triggered by large changes in the concentrations of transcription factors and therefore large differences in their stoichiometric ratios. Whether cells can elicit transitions using modest changes in the ratios of co-expressed factors is unclear. Here, we investigate how cells in the Drosophila eye resolve state transitions by quantifying the expression dynamics of the ETS transcription factors Pnt and Yan. Eye progenitor cells maintain a relatively constant ratio of Pnt/Yan protein, despite expressing both proteins with pulsatile dynamics. A rapid and sustained twofold increase in the Pnt/Yan ratio accompanies transitions to photoreceptor fates. Genetic perturbations that modestly disrupt the Pnt/Yan ratio produce fate transition defects consistent with the","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-05-28T13:00:02.199Z","creation":"2026-04-08T02:40:37.541Z"},"accession":"S-EPMC10163347","cross_references":{"pubmed":["36942737"],"doi":["10.1242/dev.201467"]}}