biostudies-literatureSullivan SNCATS NIH HHSNICHD NIH HHSNIA NIH HHSNIDA NIH HHSNHLBI NIH HHSNIMH NIH HHSNIAMS NIH HHSe112-e120https://www.ebi.ac.uk/biostudies/studies/S-EPMC10164352biostudies-literatureUnknown43(4)<h4>Background</h4>Microvascular measures of vascular dysfunction during acute mental stress may be important determinants of major adverse cardiovascular events (MACE), especially among younger and middle-aged women survivors of an acute myocardial infarction.<h4>Methods</h4>In the MIMS2 study (Myocardial Infarction and Mental Stress 2), individuals who had been hospitalized for a myocardial infarction in the past 8 months were prospectively followed for 5 years. MACE was defined as a composite index of cardiovascular death and first/recurring events for nonfatal myocardial infarction and hospitalizations for heart failure. Reactive hyperemia index and flow-mediated dilation were used to measure microvascular and endothelial function, respectively, before and 30 minutes after a public-speArteriosclerosis, thrombosis, and vascular biologySex Differences in Vascular Response to Mental Stress and Adverse Cardiovascular Events Among Patients With Ischemic Heart Disease.PMC10164352R01 HL109413UG3 DA048502L30 HL148912UH3 DA048502R01 MH120262UL1 TR002378K12 AR084234T32 HL007745T32 HL130025U54 AG062334K01 HL149982K12 HD085850Sullivan SYoung AHammadah MLewis TTHu YBremner JDMehta PKQuyyumi AAGarcia MAlmuwaqqat ZAlkhoder AShah AJMoazzami KElon LVaccarino VLima BBJajeh MNfalseSex Differences in Vascular Response to Mental Stress and Adverse Cardiovascular Events Among Patients With Ischemic Heart Disease.<h4>Background</h4>Microvascular measures of vascular dysfunction during acute mental stress may be important determinants of major adverse cardiovascular events (MACE), especially among younger and middle-aged women survivors of an acute myocardial infarction.<h4>Methods</h4>In the MIMS2 study (Myocardial Infarction and Mental Stress 2), individuals who had been hospitalized for a myocardial infarction in the past 8 months were prospectively followed for 5 years. MACE was defined as a composite index of cardiovascular death and first/recurring events for nonfatal myocardial infarction and hospitalizations for heart failure. Reactive hyperemia index and flow-mediated dilation were used to measure microvascular and endothelial function, respectively, before and 30 minutes after a public-spe2023-01-01T00:00:00Z2023 Apr2025-04-04T20:15:42.548Z2025-04-04T20:15:42.548ZS-EPMC101643523685762810.1161/ATVBAHA.122.31857610.1161/atvbaha.122.318576