{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chang YC"],"funding":["NIGMS NIH HHS"],"pagination":["1389-1404"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10164362"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(6)"],"pubmed_abstract":["<h4>Background</h4>Vagal reflexes regulate homeostasis in visceral organs and systems through afferent and efferent neurons and nerve fibers. Small, unmyelinated, C-type afferents comprise over 80% of fibers in the vagus and form the sensory arc of autonomic reflexes of the gut, lungs, heart and vessels and the immune system. Selective bioelectronic activation of C-afferents could be used to mechanistically study and treat diseases of peripheral organs in which vagal reflexes are involved, but it has not been achieved.<h4>Methods</h4>We stimulated the vagus in rats and mice using trains of kHz-frequency stimuli. Stimulation effects were assessed using neuronal c-Fos expression, physiological and nerve fiber responses, optogenetic and computational methods.<h4>Results</h4>Intermittent kHz s"],"journal":["Brain stimulation"],"pubmed_title":["kHz-frequency electrical stimulation selectively activates small, unmyelinated vagus afferents."],"pmcid":["PMC10164362"],"funding_grant_id":["R35 GM118182"],"pubmed_authors":["Lin Q","Mughrabi I","Ahmed U","Tracey KJ","Zanos S","Ashville J","Guo T","Jayaprakash N","Gerber M","Al-Abed Y","Daytz A","Chang YC","Gabalski AH","Wu YC","Abbas A","Dokos S","Datta-Chaudhuri T","Rieth L"],"additional_accession":[]},"is_claimable":false,"name":"kHz-frequency electrical stimulation selectively activates small, unmyelinated vagus afferents.","description":"<h4>Background</h4>Vagal reflexes regulate homeostasis in visceral organs and systems through afferent and efferent neurons and nerve fibers. Small, unmyelinated, C-type afferents comprise over 80% of fibers in the vagus and form the sensory arc of autonomic reflexes of the gut, lungs, heart and vessels and the immune system. Selective bioelectronic activation of C-afferents could be used to mechanistically study and treat diseases of peripheral organs in which vagal reflexes are involved, but it has not been achieved.<h4>Methods</h4>We stimulated the vagus in rats and mice using trains of kHz-frequency stimuli. Stimulation effects were assessed using neuronal c-Fos expression, physiological and nerve fiber responses, optogenetic and computational methods.<h4>Results</h4>Intermittent kHz s","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov-Dec","modification":"2025-04-21T22:39:08.056Z","creation":"2025-04-05T18:50:53.368Z"},"accession":"S-EPMC10164362","cross_references":{"pubmed":["36241025"],"doi":["10.1016/j.brs.2022.09.015"]}}