{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gautam Y"],"funding":["NIDDK NIH HHS","NIDA NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NHGRI NIH HHS","National Institutes of Health"],"pagination":["1337-1350"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10164699"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["151(5)"],"pubmed_abstract":["<h4>Background</h4>Eosinophilic esophagitis (EoE), a chronic allergic inflammatory disease, is linked to multiple genetic risk factors, but studies have focused on populations of European ancestry. Few studies have assessed Black or African American (AA) populations for loci involved in EoE susceptibility.<h4>Objective</h4>We performed admixture mapping (AM) and genome-wide association study (GWAS) of EoE using participants from AA populations.<h4>Methods</h4>We conducted AM and GWAS of EoE using 137 EoE cases and 1465 healthy controls from the AA population. Samples were genotyped using molecular evolutionary genetics analysis (MEGA). Genotype imputation was carried out with the Consortium on Asthma Among African-Ancestry Populations in the Americas (CAAPA) reference panel using the Michi"],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans."],"pmcid":["PMC10164699"],"funding_grant_id":["R01 DA024355","R01 HL132344","U54 AI117804","P30 DK078392","R01 HG011411","R21 AI157363"],"pubmed_authors":["Spergel J","Kottyan L","Leung J","Caldwell J","Mersha TB","Aceves S","Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) investigators","Khoury P","Rothenberg ME","Hirano I","Peterson K","Chehade M","Dellon ES","Wechsler J","Gupta SK","Menard-Katcher P","Davis C","Gautam Y","Gonsalves NP","Furuta G","Falk G"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans.","description":"<h4>Background</h4>Eosinophilic esophagitis (EoE), a chronic allergic inflammatory disease, is linked to multiple genetic risk factors, but studies have focused on populations of European ancestry. Few studies have assessed Black or African American (AA) populations for loci involved in EoE susceptibility.<h4>Objective</h4>We performed admixture mapping (AM) and genome-wide association study (GWAS) of EoE using participants from AA populations.<h4>Methods</h4>We conducted AM and GWAS of EoE using 137 EoE cases and 1465 healthy controls from the AA population. Samples were genotyped using molecular evolutionary genetics analysis (MEGA). Genotype imputation was carried out with the Consortium on Asthma Among African-Ancestry Populations in the Americas (CAAPA) reference panel using the Michi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-06-02T08:55:18.207Z","creation":"2026-04-16T03:12:53.994Z"},"accession":"S-EPMC10164699","cross_references":{"pubmed":["36400179"],"doi":["10.1016/j.jaci.2022.09.040"]}}