biostudies-literatureUnknown13(4)Cao FYGuanylate binding protein 5 (GBP5) is a member of the interferon (IFN)-inducible large guanosine triphosphate hydrolases (GTPase) family that regulates cell-autonomous immunity and malignant tumor transformation. However, its specific roles and underlying mechanisms GBP5 in gastric cancer (GC) remain unknown. In this study, we aimed to determine the role GBP5 and underlying mechanism of <i>GBP5</i> in GC cell progression. Potential oncogenic roles of <i>GBP5</i> in GC as well as its relationship with the tumor immune microenvironment (TIME) were comprehensively evaluated using bioinformatics analysis. Protein expression levels of GBP5 and their correlation with clinicopathological features of patients were assessed using immunohistochemistry. In addition, diverse in vitro functional experiAmerican journal of cancer research1310-1328https://www.ebi.ac.uk/biostudies/studies/S-EPMC10164808biostudies-literatureGuanylate binding protein 5 accelerates gastric cancer progression via the <i>JAK1-STAT1/GBP5/CXCL8</i> positive feedback loop.PMC10164808Wang CHZhao QCHe XBSong DLi KYang CMa MZLi XZheng YBSu STong SLTao GCCao FYfalseGuanylate binding protein 5 accelerates gastric cancer progression via the <i>JAK1-STAT1/GBP5/CXCL8</i> positive feedback loop.Guanylate binding protein 5 (GBP5) is a member of the interferon (IFN)-inducible large guanosine triphosphate hydrolases (GTPase) family that regulates cell-autonomous immunity and malignant tumor transformation. However, its specific roles and underlying mechanisms GBP5 in gastric cancer (GC) remain unknown. In this study, we aimed to determine the role GBP5 and underlying mechanism of <i>GBP5</i> in GC cell progression. Potential oncogenic roles of <i>GBP5</i> in GC as well as its relationship with the tumor immune microenvironment (TIME) were comprehensively evaluated using bioinformatics analysis. Protein expression levels of GBP5 and their correlation with clinicopathological features of patients were assessed using immunohistochemistry. In addition, diverse in vitro functional experi2023-01-01T00:00:00Z20232025-04-05T16:14:10.416Z2025-04-05T16:14:10.416ZS-EPMC1016480837168340