{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sanyal AJ"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["693-703"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10165617"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["78(4)"],"pubmed_abstract":["<h4>Background & aims</h4>Despite recent progress, non-invasive tests for the diagnostic assessment and monitoring of non-alcoholic fatty liver disease (NAFLD) remain an unmet need. Herein, we aimed to identify diagnostic signatures of the key histological features of NAFLD.<h4>Methods</h4>Using modified-aptamer proteomics, we assayed 5,220 proteins in each of 2,852 single serum samples from 636 individuals with histologically confirmed NAFLD. We developed and validated dichotomized protein-phenotype models to identify clinically relevant severities of steatosis (grade 0 vs. 1-3), hepatocellular ballooning (0 vs. 1 or 2), lobular inflammation (0-1 vs. 2-3) and fibrosis (stages 0-1 vs. 2-4).<h4>Results</h4>The AUCs of the four protein models, based on 37 analytes (18 not previously linked t"],"journal":["Journal of hepatology"],"pubmed_title":["Defining the serum proteomic signature of hepatic steatosis, inflammation, ballooning and fibrosis in non-alcoholic fatty liver disease."],"pmcid":["PMC10165617"],"funding_grant_id":["UL1 TR000058","R01 DK121378","UL1 TR001442","UL1 TR000436","UL1 TR000439","U01 DK061718","U01 DK061737","U01 DK061738","P01 HL147835","U24 DK061730","R01 DK124318","UL1 TR000100","UL1 TR000006","U01 DK061732","U01 DK061713","UL1 TR000004","U01 DK061734","UL1 TR000423","U01 DK061731","UL1 TR000448","U01 DK061730","U01 DK130190","U01 DK061728","R01 DK106419","P30 DK120515"],"pubmed_authors":["Williams SA","Kowdley KV","Tonascia J","Williams J","Biegel H","Chalasani N","Diehl AM","Kleiner DE","Alexander L","Yates KP","Ostroff R","Neuschwander-Tetri BA","Loomba R","Sanyal AJ","Lavine JE","Behling C","Jia Y","Dasarathy S","Hameed B","Karpen SJ"],"additional_accession":[]},"is_claimable":false,"name":"Defining the serum proteomic signature of hepatic steatosis, inflammation, ballooning and fibrosis in non-alcoholic fatty liver disease.","description":"<h4>Background & aims</h4>Despite recent progress, non-invasive tests for the diagnostic assessment and monitoring of non-alcoholic fatty liver disease (NAFLD) remain an unmet need. Herein, we aimed to identify diagnostic signatures of the key histological features of NAFLD.<h4>Methods</h4>Using modified-aptamer proteomics, we assayed 5,220 proteins in each of 2,852 single serum samples from 636 individuals with histologically confirmed NAFLD. We developed and validated dichotomized protein-phenotype models to identify clinically relevant severities of steatosis (grade 0 vs. 1-3), hepatocellular ballooning (0 vs. 1 or 2), lobular inflammation (0-1 vs. 2-3) and fibrosis (stages 0-1 vs. 2-4).<h4>Results</h4>The AUCs of the four protein models, based on 37 analytes (18 not previously linked t","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-05-28T08:22:08.55Z","creation":"2025-04-05T21:09:33.608Z"},"accession":"S-EPMC10165617","cross_references":{"pubmed":["36528237"],"doi":["10.1016/j.jhep.2022.11.029"]}}