{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Timoshevskaya N"],"funding":["NIGMS NIH HHS"],"pagination":["112263"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10166183"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(3)"],"pubmed_abstract":["Programmed DNA loss is a gene silencing mechanism that is employed by several vertebrate and nonvertebrate lineages, including all living jawless vertebrates and songbirds. Reconstructing the evolution of somatically eliminated (germline-specific) sequences in these species has proven challenging due to a high content of repeats and gene duplications in eliminated sequences and a corresponding lack of highly accurate and contiguous assemblies for these regions. Here, we present an improved assembly of the sea lamprey (Petromyzon marinus) genome that was generated using recently standardized methods that increase the contiguity and accuracy of vertebrate genome assemblies. This assembly resolves highly contiguous, somatically retained chromosomes and at least one germline-specific chromosom"],"journal":["Cell reports"],"pubmed_title":["An improved germline genome assembly for the sea lamprey Petromyzon marinus illuminates the evolution of germline-specific chromosomes."],"pmcid":["PMC10166183"],"funding_grant_id":["F32 GM087919","R35 GM130349","R01 GM104123"],"pubmed_authors":["Timoshevskiy VA","Yandell M","Robb SMC","Formenti G","Sims Y","Narum SR","Haase B","Fedrigo O","Krumlauf R","Howe K","Saraceno C","Timoshevskaya N","Smith JJ","Eskut KI","Hess JE","Parker HJ","Lampman RT","Miller AK","Jarvis ED","Balacco JR","Baker CF","Mountcastle J","Gemmell NJ","Holt C","Pelan S"],"additional_accession":[]},"is_claimable":false,"name":"An improved germline genome assembly for the sea lamprey Petromyzon marinus illuminates the evolution of germline-specific chromosomes.","description":"Programmed DNA loss is a gene silencing mechanism that is employed by several vertebrate and nonvertebrate lineages, including all living jawless vertebrates and songbirds. Reconstructing the evolution of somatically eliminated (germline-specific) sequences in these species has proven challenging due to a high content of repeats and gene duplications in eliminated sequences and a corresponding lack of highly accurate and contiguous assemblies for these regions. Here, we present an improved assembly of the sea lamprey (Petromyzon marinus) genome that was generated using recently standardized methods that increase the contiguity and accuracy of vertebrate genome assemblies. This assembly resolves highly contiguous, somatically retained chromosomes and at least one germline-specific chromosom","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-05-28T08:24:59.722Z","creation":"2025-04-05T21:09:27.708Z"},"accession":"S-EPMC10166183","cross_references":{"pubmed":["36930644"],"doi":["10.1016/j.celrep.2023.112263"]}}