{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["58"],"submitter":["Dominguez-Valentin M"],"pubmed_abstract":["<h4>Background</h4>The Prospective Lynch Syndrome Database (PLSD) collates information on carriers of pathogenic or likely pathogenic MMR variants (<i>path_MMR</i>) who are receiving medical follow-up, including colonoscopy surveillance, which aims to the achieve early diagnosis and treatment of cancers. Here we use the most recent PLSD cohort that is larger and has wider geographical representation than previous versions, allowing us to present mortality as an outcome, and median ages at cancer diagnoses for the first time.<h4>Methods</h4>The PLSD is a prospective observational study without a control group that was designed in 2012 and updated up to October 2022. Data for 8500 carriers of <i>path_MMR</i> variants from 25 countries were included, providing 71,713 years of follow up. Cumul"],"journal":["EClinicalMedicine"],"pagination":["101909"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10166779"],"repository":["biostudies-literature"],"pubmed_title":["Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database."],"pmcid":["PMC10166779"],"pubmed_authors":["Shah M","Haile RW","Shah P","Crosbie E","Seppala TT","Nakken S","Le Marchand L","Sunde L","Pavicic W","Tibiletti MG","Burn J","Lepisto A","Della Valle A","Bertario L","Levi Z","Katz LH","Monahan K","Bernstein I","Plazzer JP","Moreira L","Bohorquez M","Sijmons R","Nascimento ID","Apolinario da Silva L","Thomas H","Kennelly R","Perne C","Thomas L","Gallinger S","Advani SH","Engel C","Burgdorf SK","Lindor N","Bonanni B","Martin CA","Newcomb PA","Neffa F","Haupt S","Lopez-Koestner F","Peltomaki P","Win AK","Gluck N","Rosner G","Duenas N","Fruscio R","Lindblom A","Rossi NT","Laish I","Pylvanainen K","Green K","Ruiz-Banobre J","Cavestro GM","Sanchez A","Zarand A","Esperon P","Weitz J","Vangala D","Redler S","Torrezan GT","Sampson JR","Moslein G","Schmiegel W","Goldberg Y","Vainer E","Holinski-Feder E","Winship I","Greenblatt M","Evans DG","Renkonen-Sinisalo L","Hill J","Therkildsen C","Dominguez-Valentin M","Abu-Freha N","Vaccaro C","Rahner N","Moller P","Hovig E","Buttner R","Kariv R","von Knebel Doeberitz M","Aretz S","Mints M","Ten Broeke SW","Macrae F","Lino-Silva LS","Thibodeau SN","Carraro DM","Vidal JB","Pineda M","Capella G","Tjandra D","Sheth H","Steinke-Lange V","Alvarez-Valenzuela K","Madsen MG","Buchanan DD","Lalloo F","Nielsen M","Schrock E","Half E","Loeffler M","Figueiredo J","Laghi L","Horisberger K","Heuveline V","Balaguer F","Rossi BM","Debniak T","Stakelum A","Bassaneze T","Heinimann K","Winter D","Hopper JL","Jenkins MA","Huneburg R","Mecklin JP"],"additional_accession":[]},"is_claimable":false,"name":"Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database.","description":"<h4>Background</h4>The Prospective Lynch Syndrome Database (PLSD) collates information on carriers of pathogenic or likely pathogenic MMR variants (<i>path_MMR</i>) who are receiving medical follow-up, including colonoscopy surveillance, which aims to the achieve early diagnosis and treatment of cancers. Here we use the most recent PLSD cohort that is larger and has wider geographical representation than previous versions, allowing us to present mortality as an outcome, and median ages at cancer diagnoses for the first time.<h4>Methods</h4>The PLSD is a prospective observational study without a control group that was designed in 2012 and updated up to October 2022. Data for 8500 carriers of <i>path_MMR</i> variants from 25 countries were included, providing 71,713 years of follow up. Cumul","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-05T16:12:17.052Z","creation":"2025-04-05T16:12:17.052Z"},"accession":"S-EPMC10166779","cross_references":{"pubmed":["37181409"],"doi":["10.1016/j.eclinm.2023.101909"]}}