{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(17)"],"submitter":["Alghamdi ZS"],"funding":["Ministry of Education ? Kingdom of Saudi Arabi","Imam Abdulrahman Bin Faisal University"],"pubmed_abstract":["An efficient synthesis of <i>s</i>-tetrazines by solid-phase methods is described. This synthesis route was compatible with different solid-phase resins and linkers and did not require metal catalysts or high temperatures. Monosubstituted tetrazines were routinely synthesized using thiol-promoted chemistry, using dichloromethane as a carbon source, while disubstituted unsymmetrical aryl or alkyl tetrazines were synthesized using readily available nitriles. This efficient approach enabled the synthesis of <i>s</i>-tetrazines in high yields (70-94%), eliminating the classical solution-phase problems of mixtures of symmetrical and unsymmetrical tetrazines, with only a single final purification step required, and paves the way to the rapid synthesis of <i>s</i>-tetrazines with various applicat"],"journal":["Organic letters"],"pagination":["3104-3108"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10167685"],"repository":["biostudies-literature"],"pubmed_title":["Solid-Phase Synthesis of <i>s</i>-Tetrazines."],"pmcid":["PMC10167685"],"pubmed_authors":["Alghamdi ZS","Gambardella A","Klausen M","Bradley M","Lilienkampf A"],"additional_accession":[]},"is_claimable":false,"name":"Solid-Phase Synthesis of <i>s</i>-Tetrazines.","description":"An efficient synthesis of <i>s</i>-tetrazines by solid-phase methods is described. This synthesis route was compatible with different solid-phase resins and linkers and did not require metal catalysts or high temperatures. Monosubstituted tetrazines were routinely synthesized using thiol-promoted chemistry, using dichloromethane as a carbon source, while disubstituted unsymmetrical aryl or alkyl tetrazines were synthesized using readily available nitriles. This efficient approach enabled the synthesis of <i>s</i>-tetrazines in high yields (70-94%), eliminating the classical solution-phase problems of mixtures of symmetrical and unsymmetrical tetrazines, with only a single final purification step required, and paves the way to the rapid synthesis of <i>s</i>-tetrazines with various applicat","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-22T00:31:53.158Z","creation":"2025-04-05T19:36:41.174Z"},"accession":"S-EPMC10167685","cross_references":{"pubmed":["37083299"],"doi":["10.1021/acs.orglett.3c00955"]}}