{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31"],"submitter":["Xiao X"],"pubmed_abstract":["<h4>Objectives</h4>The mid-palatal expansion technique is commonly used to correct maxillary constriction in dental clinics. However, there is a tendency for it to relapse, and the key molecules responsible for modulating bone formation remain elusive. Thus, this study aimed to investigate whether signal transducer and activator of transcription 3 (STAT3) activation contributes to osteoblast-mediated bone formation during palatal expansion and relapse.<h4>Methodology</h4>In total, 30 male Wistar rats were randomly allocated into Ctrl (control), E (expansion only), and E+Stattic (expansion plus STAT3-inhibitor, Stattic) groups. Micro-computed tomography, micromorphology staining, and immunohistochemistry of the mid-palatal suture were performed on days 7 and 14. In vitro cyclic tensile stre"],"journal":["Journal of applied oral science : revista FOB"],"pagination":["e20230009"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10167947"],"repository":["biostudies-literature"],"pubmed_title":["Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse."],"pmcid":["PMC10167947"],"pubmed_authors":["Xin L","Zheng X","Chen J","Wang S","Xiao X","Zhai Q","Song J"],"additional_accession":[]},"is_claimable":false,"name":"Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse.","description":"<h4>Objectives</h4>The mid-palatal expansion technique is commonly used to correct maxillary constriction in dental clinics. However, there is a tendency for it to relapse, and the key molecules responsible for modulating bone formation remain elusive. Thus, this study aimed to investigate whether signal transducer and activator of transcription 3 (STAT3) activation contributes to osteoblast-mediated bone formation during palatal expansion and relapse.<h4>Methodology</h4>In total, 30 male Wistar rats were randomly allocated into Ctrl (control), E (expansion only), and E+Stattic (expansion plus STAT3-inhibitor, Stattic) groups. Micro-computed tomography, micromorphology staining, and immunohistochemistry of the mid-palatal suture were performed on days 7 and 14. In vitro cyclic tensile stre","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T10:19:32.173Z","creation":"2025-02-19T00:12:32.463Z"},"accession":"S-EPMC10167947","cross_references":{"pubmed":["37162107"],"doi":["10.1590/1678-7757-2023-0009"]}}