{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Morse K"],"funding":["NICHD NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["Alternative transcription start sites can affect transcript isoform diversity and translation levels. In a recently described form of gene regulation, coordinated transcriptional and translational interference results in transcript isoform-dependent changes in protein expression. Specifically, a long undecoded transcript isoform (LUTI) is transcribed from a gene-distal promoter, interfering with expression of the gene-proximal promoter. While transcriptional and chromatin features associated with LUTI expression have been described, the mechanism underlying LUTI-based transcriptional interference is not well understood. Using an unbiased genetic approach followed by integrated genomic analysis, we uncovered that the Swi/Snf chromatin remodeling complex is required for co-transcriptional nu"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.04.27.538572"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10168381"],"repository":["biostudies-literature"],"pubmed_title":["Swi/Snf Chromatin Remodeling Regulates Transcriptional Interference and Gene Repression."],"pmcid":["PMC10168381"],"funding_grant_id":["F31 HD103399","R01 GM140005"],"pubmed_authors":["Swerdlow S","Morse K","Unal E"],"additional_accession":[]},"is_claimable":false,"name":"Swi/Snf Chromatin Remodeling Regulates Transcriptional Interference and Gene Repression.","description":"Alternative transcription start sites can affect transcript isoform diversity and translation levels. In a recently described form of gene regulation, coordinated transcriptional and translational interference results in transcript isoform-dependent changes in protein expression. Specifically, a long undecoded transcript isoform (LUTI) is transcribed from a gene-distal promoter, interfering with expression of the gene-proximal promoter. While transcriptional and chromatin features associated with LUTI expression have been described, the mechanism underlying LUTI-based transcriptional interference is not well understood. Using an unbiased genetic approach followed by integrated genomic analysis, we uncovered that the Swi/Snf chromatin remodeling complex is required for co-transcriptional nu","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-05-16T03:16:01.637Z","creation":"2025-04-04T10:24:07.561Z"},"accession":"S-EPMC10168381","cross_references":{"pubmed":["37162931"],"doi":["10.1101/2023.04.27.538572"]}}